Can we test for hereditary cancer at 18 years when we start surveillance at 25? Patient reported outcomes.

Overview of attention for article published in Familial Cancer, April 2013
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  • In the top 5% of all articles scored by Altmetric
  • One of the highest-scoring articles from this source (#2 of 146)
  • High score compared to articles of the same age (93rd percentile)
  • High score compared to articles of the same age and source (90th percentile)

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27 tweeters

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2 Mendeley
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Article title
Can we test for hereditary cancer at 18 years when we start surveillance at 25? Patient reported outcomes.
Published in
Familial Cancer, April 2013
DOI 10.1007/s10689-013-9644-9
Pubmed ID
Authors

Sie AS, Prins JB, Spruijt L, Kets CM, Hoogerbrugge N

Abstract

DNA-testing for BRCA1/2 or Lynch syndrome is possible from the age of 18 years, although surveillance usually starts at 25. Some patients regret their decision of testing before age 25. This retrospective study evaluates whether the testing age should be above 25 years to prevent adverse effects such as regret or decisional conflict, by determining the percentage and characteristics of patients reporting these problems. 111 of 219 patients (51%) tested for BRCA1/2 mutations or Lynch syndrome between 18 and 25 years from July 1996 to February 2011, returned self-report surveys. Primary measures were regret, decisional conflict and family influence. Secondary measures included quality of life (QoL), coping style, impact of genetic testing, and risk perception. Median age was 27 [21-40] years, with 86% female. 73% was tested for BRCA1/2, 27% for Lynch syndrome. Only 3% reported regret, however 39% had moderate (32%) to severe (7%) decisional conflict. Regression analysis revealed that decisional conflict was associated with more monitoring/neutral coping style (p < 0.03) or paternal/no family mutation (p < 0.02); there were no differences in QoL, impact or risk perception. 42% were mutation carriers, showing equal decisional conflict to non-carriers. 68% would recommend testing <25 years; 77% desired surveillance <25 years if a mutation carrier. Almost no patient tested for hereditary cancer between 18 and 25 years regretted this decision. A third reported retrospective decisional conflict, especially those actively seeking information when faced with a threat and/or those with a paternal or unknown inheritance. These patients may benefit from decisional support and personalized information.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 2 Mendeley readers of this article. Click here to see the article's page on the Mendeley website.

Geographical breakdown

Country Count As %
Unknown 2 100%

Demographic breakdown

Readers by professional status Count As %
Ph.D. Student 1 50%
Post Doc 1 50%
Readers by discipline Count As %
Medicine 2 100%

Score in context

This article has an Altmetric score of 18.55. This is our high-level measure of the quality and quantity of online attention that this article has received. This score was calculated when the article was last mentioned on 01 September 2013.
All articles
#143,040
of 3,632,140 articles
Articles in Familial Cancer
#2
of 146 articles
Articles of similar age
#5,309
of 84,595 articles
Articles of similar age in Familial Cancer
#2
of 22 articles
Altmetric has tracked 3,632,140 articles across all sources so far. Compared to these this article has done particularly well and is in the 96th percentile: it's in the top 5% of all articles ever tracked by Altmetric.
So far Altmetric has tracked 146 articles from this source. They typically receive a little less attention than average, with a mean score of 2.9. This article has done particularly well, scoring higher than 98% of its peers.
Older articles will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this score to the 84,595 tracked articles that were published within six weeks on either side of this one in any source. This article has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this article to 22 articles from the same source and published within six weeks on either side of this one. This article has done particularly well, scoring higher than 90% of its contemporaries.