Title |
Imaging of serotonin transporters with [123I]FP-CIT SPECT in the human hypothalamus
|
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Published in |
EJNMMI Research, April 2013
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DOI | 10.1186/2191-219x-3-34 |
Pubmed ID | |
Authors |
Anke J Borgers, Anneke Alkemade, Elsmarieke M Van de Giessen, Madeleine L Drent, Jan Booij, Peter H Bisschop, Eric Fliers |
Abstract |
Serotonergic neurons in the rodent hypothalamus are implicated in key neuroendocrine and metabolic functions, including circadian rhythmicity. However, the assessment of the serotonergic system in the human hypothalamus in vivo is difficult as delineation of the hypothalamus is cumbersome with conventional region-of-interest analysis. In the present study, we aimed to develop a method to visualize serotonin transporters (SERT) in the hypothalamus. Additionally, we tested the hypothesis that hypothalamic SERT binding ratios are different between patients with hypothalamic impairment (HI), pituitary insufficiency (PI), and control subjects (C). |
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