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Compensation of the Metabolic Costs of Antibiotic Resistance by Physiological Adaptation in Escherichia coli

Overview of attention for article published in Antimicrobial Agents and Chemotherapy, May 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

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1 policy source
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7 X users
patent
1 patent
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2 Wikipedia pages

Citations

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70 Dimensions

Readers on

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171 Mendeley
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Title
Compensation of the Metabolic Costs of Antibiotic Resistance by Physiological Adaptation in Escherichia coli
Published in
Antimicrobial Agents and Chemotherapy, May 2013
DOI 10.1128/aac.02096-12
Pubmed ID
Authors

Nadine Händel, J. Merijn Schuurmans, Stanley Brul, Benno H. ter Kuile

Abstract

Antibiotic resistance is often associated with metabolic costs. To investigate the metabolic consequences of antibiotic resistance, the genomic and transcriptomic profiles of an amoxicillin-resistant Escherichia coli strain and the wild type it was derived from were compared. A total of 125 amino acid substitutions and 7 mutations that were located <1,000 bp upstream of differentially expressed genes were found in resistant cells. However, broad induction and suppression of genes were observed when comparing the expression profiles of resistant and wild-type cells. Expression of genes involved in cell wall maintenance, DNA metabolic processes, cellular stress response, and respiration was most affected in resistant cells regardless of the absence or presence of amoxicillin. The SOS response was downregulated in resistant cells. The physiological effect of the acquisition of amoxicillin resistance in cells grown in chemostat cultures consisted of an initial increase in glucose consumption that was followed by an adaptation process. Furthermore, no difference in maintenance energy was observed between resistant and sensitive cells. In accordance with the transcriptomic profile, exposure of resistant cells to amoxicillin resulted in reduced salt and pH tolerance. Taken together, the results demonstrate that the acquisition of antibiotic resistance in E. coli is accompanied by specifically reorganized metabolic networks in order to circumvent metabolic costs. The overall effect of the acquisition of resistance consists not so much of an extra energy requirement, but more a reduced ecological range.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 171 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 2 1%
Unknown 169 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 36 21%
Student > Bachelor 27 16%
Student > Master 21 12%
Researcher 16 9%
Other 12 7%
Other 23 13%
Unknown 36 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 45 26%
Biochemistry, Genetics and Molecular Biology 34 20%
Medicine and Dentistry 12 7%
Immunology and Microbiology 8 5%
Pharmacology, Toxicology and Pharmaceutical Science 6 4%
Other 23 13%
Unknown 43 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2022.
All research outputs
#2,590,944
of 25,529,543 outputs
Outputs from Antimicrobial Agents and Chemotherapy
#1,362
of 15,606 outputs
Outputs of similar age
#21,564
of 207,971 outputs
Outputs of similar age from Antimicrobial Agents and Chemotherapy
#11
of 151 outputs
Altmetric has tracked 25,529,543 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,606 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 207,971 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 151 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.