Title |
Serum Iron Levels and the Risk of Parkinson Disease: A Mendelian Randomization Study
|
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Published in |
PLOS Medicine, June 2013
|
DOI | 10.1371/journal.pmed.1001462 |
Pubmed ID | |
Authors |
Irene Pichler, Fabiola Del Greco M., Martin Gögele, Christina M. Lill, Lars Bertram, Chuong B. Do, Nicholas Eriksson, Tatiana Foroud, Richard H. Myers, Michael Nalls, Margaux F. Keller, Beben Benyamin, John B. Whitfield, Peter P. Pramstaller, Andrew A. Hicks, John R. Thompson, Cosetta Minelli |
Abstract |
Although levels of iron are known to be increased in the brains of patients with Parkinson disease (PD), epidemiological evidence on a possible effect of iron blood levels on PD risk is inconclusive, with effects reported in opposite directions. Epidemiological studies suffer from problems of confounding and reverse causation, and mendelian randomization (MR) represents an alternative approach to provide unconfounded estimates of the effects of biomarkers on disease. We performed a MR study where genes known to modify iron levels were used as instruments to estimate the effect of iron on PD risk, based on estimates of the genetic effects on both iron and PD obtained from the largest sample meta-analyzed to date. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 3 | 10% |
Canada | 3 | 10% |
Germany | 3 | 10% |
Australia | 1 | 3% |
Saudi Arabia | 1 | 3% |
Mexico | 1 | 3% |
Spain | 1 | 3% |
Argentina | 1 | 3% |
Other | 4 | 14% |
Unknown | 8 | 28% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 2 | 7% |
Scientists | 2 | 7% |
Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 3 | 2% |
Italy | 1 | <1% |
Ecuador | 1 | <1% |
India | 1 | <1% |
Spain | 1 | <1% |
Canada | 1 | <1% |
Unknown | 174 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 43 | 23% |
Student > Ph. D. Student | 39 | 21% |
Student > Bachelor | 23 | 12% |
Student > Master | 13 | 7% |
Other | 11 | 6% |
Other | 35 | 19% |
Unknown | 24 | 13% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 23 | 12% |
Neuroscience | 12 | 6% |
Economics, Econometrics and Finance | 8 | 4% |
Other | 26 | 14% |
Unknown | 35 | 19% |