Title |
Monitoring Prednisolone and Prednisone in Saliva
|
---|---|
Published in |
Therapeutic Drug Monitoring, August 2013
|
DOI | 10.1097/ftd.0b013e3182899ea2 |
Pubmed ID | |
Authors |
Nynke Teeninga, Zheng Guan, Jan Freijer, An F. C. Ruiter, Mariëtte T. Ackermans, Joana E. Kist-van Holthe, Teun van Gelder, Jeroen Nauta |
Abstract |
Prednisolone (PLN) is a widely used corticosteroid in a variety of immune-mediated diseases. Treatment regimes generally consist of empirically derived treatment doses, whereas therapeutic response among patients is highly variable. Drug monitoring of serum PLN levels might support a more rational approach to dose selection, yet is invasive and laborious. In analogy to cortisol, salivary PLN may offer a good alternative for serum PLN, being a representative approximation of free serum PLN. The aims of this study were to evaluate the correlation between free serum and salivary PLN levels and to quantify this relationship within a population pharmacokinetic model. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 50% |
United States | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 22 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 27% |
Student > Master | 3 | 14% |
Student > Doctoral Student | 2 | 9% |
Lecturer | 1 | 5% |
Other | 1 | 5% |
Other | 4 | 18% |
Unknown | 5 | 23% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 2 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 9% |
Nursing and Health Professions | 1 | 5% |
Social Sciences | 1 | 5% |
Other | 3 | 14% |
Unknown | 4 | 18% |