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Cyclosporine versus everolimus: effects on the glomerulus

Overview of attention for article published in Clinical Transplantation, June 2013
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (69th percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

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Title
Cyclosporine versus everolimus: effects on the glomerulus
Published in
Clinical Transplantation, June 2013
DOI 10.1111/ctr.12144
Pubmed ID
Authors

Marije C. Baas, Jesper Kers, Sandrine Florquin, Johan W. de Fijter, Jaap J. Homan van der Heide, Marius A. van den Bergh Weerman, Ineke J. M. ten Berge, Frederike J. Bemelman

Abstract

Inhibitors of the mammalian target of rapamycin (mTOR) have been associated with proteinuria. We studied the development of proteinuria in renal transplant recipients (RTR) treated with the mTOR inhibitor everolimus in comparison with a calcineurin inhibitor. We related the presence of proteinuria to histopathological glomerular findings in two-yr protocol biopsies. In a single-center study, nested in a multicenter randomized controlled trial, we determined eGFR, proteinuria, and renal biopsy data (light- and electron microscopy) of RTR receiving prednisolone/everolimus (P/EVL) (n = 16) in comparison with patients treated with prednisolone/cyclosporine A (P/CsA) (n = 7). All patients had been on the above-described maintenance immunosuppression for 18 months. Renal function at two yr after transplantation did not differ between patients receiving P/EVL or P/CsA (eGFR 45.5 vs. 45.7 mL/min/1.73 m(2)). Proteinuria was slightly increased in P/EVL vs. P/CsA group (0.29 vs. 0.14 g/24 h, p = 0.06). There were no differences in light- or electron microscopic findings. We could not demonstrate increased podocyte effacement or changes in glomerular basement membrane (GBM) thickness in P/EVL-treated patients. In conclusion, long-term treatment with everolimus leaves the GBM and podocytes unaffected.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 15%
Student > Postgraduate 6 15%
Researcher 6 15%
Student > Ph. D. Student 6 15%
Student > Master 4 10%
Other 7 17%
Unknown 6 15%
Readers by discipline Count As %
Medicine and Dentistry 21 51%
Agricultural and Biological Sciences 5 12%
Neuroscience 2 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Arts and Humanities 1 2%
Other 3 7%
Unknown 8 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2013.
All research outputs
#7,581,833
of 24,558,777 outputs
Outputs from Clinical Transplantation
#413
of 1,541 outputs
Outputs of similar age
#61,378
of 201,197 outputs
Outputs of similar age from Clinical Transplantation
#6
of 18 outputs
Altmetric has tracked 24,558,777 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 1,541 research outputs from this source. They receive a mean Attention Score of 4.9. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 201,197 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.