Title |
Risk profile and clinical outcome of symptomatic subsegmental acute pulmonary embolism
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Published in |
Blood, June 2013
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DOI | 10.1182/blood-2013-04-497545 |
Pubmed ID | |
Authors |
Paul L. den Exter, Josien van Es, Frederikus A. Klok, Lucia J. Kroft, Marieke J.H.A. Kruip, Pieter Willem Kamphuisen, Harry R. Büller, Menno V. Huisman |
Abstract |
The clinical significance of subsegmental pulmonary embolism (SSPE) remains to be determined. This study aimed to investigate whether SSPE forms a distinct subset of thromboembolic disease compared with more proximally located pulmonary embolism (PE). We analyzed 3728 consecutive patients with clinically suspected PE. SSPE patients were contrasted to patients with more proximal PE and to patients in whom suspected PE was ruled out, in regards of the prevalence of thromboembolic risk factors and the 3-month risks of recurrent venous thromboembolism (VTE) and mortality. PE was confirmed in 748 patients, of whom 116 (16%) had SSPE; PE was ruled out in 2980 patients. No differences were seen in the prevalence of VTE risk factors, the 3-month risk of recurrent VTE (3.6% vs 2.5%; P = .42), and mortality (10.7% vs 6.5%; P = .17) between patients with SSPE and those with more proximal PE. When compared with patients without PE, aged >60 years, recent surgery, estrogen use, and male gender were found to be independent predictors for SSPE, and patients with SSPE were at an increased risk of VTE during follow-up (hazard ratio: 3.8; 95% CI: 1.3-11.1). This study indicates that patients with SSPE mimic those with more proximally located PE in regards to their risk profile and clinical outcome. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 11 | 25% |
Canada | 4 | 9% |
United Kingdom | 3 | 7% |
Netherlands | 2 | 5% |
Australia | 2 | 5% |
Spain | 1 | 2% |
India | 1 | 2% |
Morocco | 1 | 2% |
New Zealand | 1 | 2% |
Other | 3 | 7% |
Unknown | 15 | 34% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 24 | 55% |
Practitioners (doctors, other healthcare professionals) | 12 | 27% |
Scientists | 5 | 11% |
Science communicators (journalists, bloggers, editors) | 3 | 7% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 2 | 2% |
France | 1 | <1% |
Brazil | 1 | <1% |
United Kingdom | 1 | <1% |
Canada | 1 | <1% |
Unknown | 123 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 27 | 21% |
Researcher | 15 | 12% |
Student > Postgraduate | 15 | 12% |
Student > Master | 11 | 9% |
Student > Bachelor | 10 | 8% |
Other | 30 | 23% |
Unknown | 21 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 86 | 67% |
Nursing and Health Professions | 4 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
Environmental Science | 1 | <1% |
Agricultural and Biological Sciences | 1 | <1% |
Other | 3 | 2% |
Unknown | 32 | 25% |