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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma
|
|---|---|
| Published in |
Nature Genetics, June 2013
|
| DOI | 10.1038/ng.2682 |
| Pubmed ID | |
| Authors |
David T W Jones, Barbara Hutter, Natalie Jäger, Andrey Korshunov, Marcel Kool, Hans-Jörg Warnatz, Thomas Zichner, Sally R Lambert, Marina Ryzhova, Dong Anh Khuong Quang, Adam M Fontebasso, Adrian M Stütz, Sonja Hutter, Marc Zuckermann, Dominik Sturm, Jan Gronych, Bärbel Lasitschka, Sabine Schmidt, Huriye Şeker-Cin, Hendrik Witt, Marc Sultan, Meryem Ralser, Paul A Northcott, Volker Hovestadt, Sebastian Bender, Elke Pfaff, Sebastian Stark, Damien Faury, Jeremy Schwartzentruber, Jacek Majewski, Ursula D Weber, Marc Zapatka, Benjamin Raeder, Matthias Schlesner, Catherine L Worth, Cynthia C Bartholomae, Christof von Kalle, Charles D Imbusch, Sylwester Radomski, Chris Lawerenz, Peter van Sluis, Jan Koster, Richard Volckmann, Rogier Versteeg, Hans Lehrach, Camelia Monoranu, Beate Winkler, Andreas Unterberg, Christel Herold-Mende, Till Milde, Andreas E Kulozik, Martin Ebinger, Martin U Schuhmann, Yoon-Jae Cho, Scott L Pomeroy, Andreas von Deimling, Olaf Witt, Michael D Taylor, Stephan Wolf, Matthias A Karajannis, Charles G Eberhart, Wolfram Scheurlen, Martin Hasselblatt, Keith L Ligon, Mark W Kieran, Jan O Korbel, Marie-Laure Yaspo, Benedikt Brors, Jörg Felsberg, Guido Reifenberger, V Peter Collins, Nada Jabado, Roland Eils, Peter Lichter |
| Abstract |
Pilocytic astrocytoma, the most common childhood brain tumor, is typically associated with mitogen-activated protein kinase (MAPK) pathway alterations. Surgically inaccessible midline tumors are therapeutically challenging, showing sustained tendency for progression and often becoming a chronic disease with substantial morbidities. Here we describe whole-genome sequencing of 96 pilocytic astrocytomas, with matched RNA sequencing (n = 73), conducted by the International Cancer Genome Consortium (ICGC) PedBrain Tumor Project. We identified recurrent activating mutations in FGFR1 and PTPN11 and new NTRK2 fusion genes in non-cerebellar tumors. New BRAF-activating changes were also observed. MAPK pathway alterations affected all tumors analyzed, with no other significant mutations identified, indicating that pilocytic astrocytoma is predominantly a single-pathway disease. Notably, we identified the same FGFR1 mutations in a subset of H3F3A-mutated pediatric glioblastoma with additional alterations in the NF1 gene. Our findings thus identify new potential therapeutic targets in distinct subsets of pilocytic astrocytoma and childhood glioblastoma. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 36% |
| Germany | 1 | 9% |
| United States | 1 | 9% |
| France | 1 | 9% |
| Unknown | 4 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 64% |
| Scientists | 2 | 18% |
| Science communicators (journalists, bloggers, editors) | 2 | 18% |
Mendeley readers
The data shown below were compiled from readership statistics for 437 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 4 | <1% |
| Japan | 4 | <1% |
| Italy | 2 | <1% |
| France | 1 | <1% |
| Czechia | 1 | <1% |
| Hungary | 1 | <1% |
| Canada | 1 | <1% |
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 420 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 105 | 24% |
| Student > Ph. D. Student | 68 | 16% |
| Student > Master | 42 | 10% |
| Other | 33 | 8% |
| Student > Bachelor | 29 | 7% |
| Other | 81 | 19% |
| Unknown | 79 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 117 | 27% |
| Agricultural and Biological Sciences | 99 | 23% |
| Biochemistry, Genetics and Molecular Biology | 75 | 17% |
| Neuroscience | 15 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 2% |
| Other | 31 | 7% |
| Unknown | 91 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 60. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2024.
All research outputs
#722,523
of 25,706,302 outputs
Outputs from Nature Genetics
#1,353
of 7,606 outputs
Outputs of similar age
#5,427
of 207,626 outputs
Outputs of similar age from Nature Genetics
#20
of 73 outputs
Altmetric has tracked 25,706,302 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,606 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.4. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 207,626 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 73 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.