Abnormal white matter microstructure in children with sensory processing disorders.

Overview of attention for article published in NeuroImage: Clinical, June 2013
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  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#2 of 414)
  • High score compared to outputs of the same age (98th percentile)
  • High score compared to outputs of the same age and source (87th percentile)

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mendeley
85 Mendeley
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9 CiteULike
Title
Abnormal white matter microstructure in children with sensory processing disorders.
Published in
NeuroImage: Clinical, June 2013
DOI 10.1016/j.nicl.2013.06.009
Pubmed ID
Authors

Julia P. Owen, Elysa J. Marco, Shivani Desai, Emily Fourie, Julia Harris, Susanna S. Hill, Anne B. Arnett, Pratik Mukherjee

Abstract

Sensory processing disorders (SPD) affect 5-16% of school-aged children and can cause long-term deficits in intellectual and social development. Current theories of SPD implicate primary sensory cortical areas and higher-order multisensory integration (MSI) cortical regions. We investigate the role of white matter microstructural abnormalities in SPD using diffusion tensor imaging (DTI). DTI was acquired in 16 boys, 8-11 years old, with SPD and 24 age-, gender-, handedness- and IQ-matched neurotypical controls. Behavior was characterized using a parent report sensory behavior measure, the Sensory Profile. Fractional anisotropy (FA), mean diffusivity (MD) and radial diffusivity (RD) were calculated. Tract-based spatial statistics were used to detect significant group differences in white matter integrity and to determine if microstructural parameters were significantly correlated with behavioral measures. Significant decreases in FA and increases in MD and RD were found in the SPD cohort compared to controls, primarily involving posterior white matter including the posterior corpus callosum, posterior corona radiata and posterior thalamic radiations. Strong positive correlations were observed between FA of these posterior tracts and auditory, multisensory, and inattention scores (r = 0.51-0.78; p < 0.001) with strong negative correlations between RD and multisensory and inattention scores (r = - 0.61-0.71; p < 0.001). To our knowledge, this is the first study to demonstrate reduced white matter microstructural integrity in children with SPD. We find that the disrupted white matter microstructure predominantly involves posterior cerebral tracts and correlates strongly with atypical unimodal and multisensory integration behavior. These findings suggest abnormal white matter as a biological basis for SPD and may also distinguish SPD from overlapping clinical conditions such as autism and attention deficit hyperactivity disorder.

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Mendeley readers

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Geographical breakdown

Country Count As %
United Kingdom 3 4%
United States 3 4%
Colombia 2 2%
Mexico 2 2%
France 2 2%
Germany 1 1%
Canada 1 1%
Unknown 71 84%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 9%
Other 3 4%
Librarian 3 4%
Unknown 71 84%
Readers by discipline Count As %
Psychology 22 26%
Medicine 19 22%
Biological Sciences 18 21%
Social Sciences 9 11%
Education 7 8%
Other 5 6%
Unknown 5 6%

Score in context

This research output has an Altmetric score of 116. This is our high-level measure of the quality and quantity of online attention that it has received. This score was calculated when the research output was last mentioned on 30 January 2016.
All research outputs
#27,274
of 4,724,370 outputs
Outputs from NeuroImage: Clinical
#2
of 414 outputs
Outputs of similar age
#913
of 91,141 outputs
Outputs of similar age from NeuroImage: Clinical
#1
of 8 outputs
Altmetric has tracked 4,724,370 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 414 research outputs from this source. They typically receive a little more attention than average, with a mean score of 5.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this score to the 91,141 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them