Title |
Overexpression of Activated Protein C is Detrimental During Severe Experimental Gram-Negative Sepsis (Melioidosis)*
|
---|---|
Published in |
Critical Care Medicine, October 2013
|
DOI | 10.1097/ccm.0b013e31828a4316 |
Pubmed ID | |
Authors |
Liesbeth M. Kager, W. Joost Wiersinga, Joris J. T. H. Roelofs, Onno J. de Boer, Joost C. M. Meijers, Berend Isermann, Cornelis van’t Veer, Tom Van der Poll |
Abstract |
The interplay between inflammation and blood coagulation is an essential part of host defense during severe pneumosepsis. Melioidosis, instigated by the Gram-negative bacterium Burkholderia pseudomallei, is a frequent cause of pneumosepsis in Southeast Asia. Patients with severe pneumosepsis, including melioidosis, have decreased circulating levels of protein C. Activated protein C has anticoagulant and anti-inflammatory properties. In this study, we aimed to investigate the effect of sustained elevated activated protein C levels on the host response during melioidosis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Thailand | 1 | 4% |
Unknown | 25 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 31% |
Researcher | 3 | 12% |
Student > Postgraduate | 3 | 12% |
Professor | 2 | 8% |
Student > Master | 2 | 8% |
Other | 4 | 15% |
Unknown | 4 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 50% |
Agricultural and Biological Sciences | 4 | 15% |
Biochemistry, Genetics and Molecular Biology | 2 | 8% |
Decision Sciences | 1 | 4% |
Psychology | 1 | 4% |
Other | 0 | 0% |
Unknown | 5 | 19% |