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Overexpression of Activated Protein C is Detrimental During Severe Experimental Gram-Negative Sepsis (Melioidosis)*

Overview of attention for article published in Critical Care Medicine, October 2013
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2 X users

Citations

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Title
Overexpression of Activated Protein C is Detrimental During Severe Experimental Gram-Negative Sepsis (Melioidosis)*
Published in
Critical Care Medicine, October 2013
DOI 10.1097/ccm.0b013e31828a4316
Pubmed ID
Authors

Liesbeth M. Kager, W. Joost Wiersinga, Joris J. T. H. Roelofs, Onno J. de Boer, Joost C. M. Meijers, Berend Isermann, Cornelis van’t Veer, Tom Van der Poll

Abstract

The interplay between inflammation and blood coagulation is an essential part of host defense during severe pneumosepsis. Melioidosis, instigated by the Gram-negative bacterium Burkholderia pseudomallei, is a frequent cause of pneumosepsis in Southeast Asia. Patients with severe pneumosepsis, including melioidosis, have decreased circulating levels of protein C. Activated protein C has anticoagulant and anti-inflammatory properties. In this study, we aimed to investigate the effect of sustained elevated activated protein C levels on the host response during melioidosis.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Thailand 1 4%
Unknown 25 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 31%
Researcher 3 12%
Student > Postgraduate 3 12%
Professor 2 8%
Student > Master 2 8%
Other 4 15%
Unknown 4 15%
Readers by discipline Count As %
Medicine and Dentistry 13 50%
Agricultural and Biological Sciences 4 15%
Biochemistry, Genetics and Molecular Biology 2 8%
Decision Sciences 1 4%
Psychology 1 4%
Other 0 0%
Unknown 5 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 July 2013.
All research outputs
#17,285,036
of 25,371,288 outputs
Outputs from Critical Care Medicine
#7,634
of 9,339 outputs
Outputs of similar age
#137,948
of 219,840 outputs
Outputs of similar age from Critical Care Medicine
#95
of 125 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,339 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.8. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 219,840 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 125 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.