Title |
Beta Sheets with a Twist: The Conformation of Helical Polyisocyanopeptides Determined by Using Vibrational Circular Dichroism
|
---|---|
Published in |
Chemistry - A European Journal, August 2013
|
DOI | 10.1002/chem.201300073 |
Pubmed ID | |
Authors |
Erik Schwartz, Vincent Liégeois, Matthieu Koepf, Pavol Bodis, Jeroen J. L. M. Cornelissen, Patrick Brocorens, David Beljonne, Roeland J. M. Nolte, Alan E. Rowan, Sander Woutersen, Benoît Champagne |
Abstract |
Detailed information on the architecture of polyisocyanopeptides based on vibrational circular dichroism (VCD) spectroscopy in combination with DFT calculations is presented. It is demonstrated that the screw sense of the helical polyisocyanides can be determined directly from the C=N-stretch vibrational region of the VCD spectrum. Analysis of the VCD signals associated with the amide I and amide II modes provides detailed information on the peptide side-chain arrangement in the polymer and indicates the presence of a helical β-sheet architecture, in which the dihedral angles are slightly different to those of natural β-sheet helices. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 5% |
Unknown | 19 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 30% |
Researcher | 5 | 25% |
Student > Bachelor | 3 | 15% |
Student > Master | 3 | 15% |
Professor | 2 | 10% |
Other | 1 | 5% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 16 | 80% |
Physics and Astronomy | 2 | 10% |
Chemical Engineering | 1 | 5% |
Engineering | 1 | 5% |