Title |
Melatonin Deficiency Hypothesis in Delirium: A Synthesis of Current Evidence
|
---|---|
Published in |
Rejuvenation Research, August 2013
|
DOI | 10.1089/rej.2012.1405 |
Pubmed ID | |
Authors |
Sophia E. de Rooij, Barbara C. van Munster |
Abstract |
The pineal hormone melatonin plays a major role in circadian sleep-wake rhythm in many mammals, including humans. Patients with acute confusional state or delirium, especially those with underlying cognitive impairment, frequently suffer from sleep disturbances and disturbed circadian rhythm. In this review, an overview is given of delirium and delirium symptoms that correspond with symptoms in dementia, such as sundowning, followed by a presentation of the circadian rhythm disorders in delirium in relation to melatonin deficiency. Finally, this review examines the therapeutic benefit of melatonin treatment in disorders related to delirium and dementia, including the placebo-controlled randomized clinical trials addressing this topic. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | <1% |
United Kingdom | 1 | <1% |
Mexico | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Luxembourg | 1 | <1% |
Unknown | 130 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 20 | 15% |
Student > Master | 18 | 13% |
Researcher | 16 | 12% |
Student > Postgraduate | 9 | 7% |
Student > Bachelor | 9 | 7% |
Other | 28 | 21% |
Unknown | 36 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 69 | 51% |
Neuroscience | 6 | 4% |
Nursing and Health Professions | 5 | 4% |
Agricultural and Biological Sciences | 5 | 4% |
Psychology | 5 | 4% |
Other | 9 | 7% |
Unknown | 37 | 27% |