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Microglia in Olfactory Bulb of AD and PD Patients

Overview of attention for article published in Brain Pathology, October 2013
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Title
Microglia in Olfactory Bulb of AD and PD Patients
Published in
Brain Pathology, October 2013
DOI 10.1111/bpa.12088
Pubmed ID
Authors

Karlijn J. Doorn, Andrea Goudriaan, Carla Blits‐Huizinga, John G.J.M. Bol, Annemieke J. Rozemuller, Piet V.J.M. Hoogland, Paul J. Lucassen, Benjamin Drukarch, Wilma D.J. van de Berg, Anne‐Marie van Dam

Abstract

The olfactory bulb (OB) is affected early in both Parkinson's (PD) and Alzheimer's disease (AD), evidenced by the presence of disease-specific protein aggregates and an early loss of olfaction. Whereas previous studies showed amoeboid microglia in the classically affected brain regions of PD and AD patients, little was known about such changes in the OB. Using a morphometric approach, a significant increase in amoeboid microglia density within the anterior olfactory nucleus (AON) of AD and PD patients was observed. These amoeboid microglia were in close apposition to β-amyloid, hyperphosphorylated tau or α-synuclein deposits, but no uptake of pathological proteins by microglia could be visualized. Subsequent analysis showed 1) no correlation between microglia and α-synuclein (PD), 2) a positive correlation with β-amyloid (AD) and 3) a negative correlation with hyperphosphorylated tau (AD). Furthermore, despite the observed pathological alterations in neurite morphology, neuronal loss was not apparent in the AON of both patient groups. Thus, we hypothesize that, in contrast to the classically affected brain regions of AD and PD patients, within the AON rather than neuronal loss, the increased density in amoeboid microglial cells, possibly in combination with neurite pathology, may contribute to functional deficits.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 <1%
Australia 1 <1%
Brazil 1 <1%
Unknown 109 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 24%
Researcher 19 17%
Student > Master 13 12%
Student > Doctoral Student 9 8%
Student > Bachelor 5 4%
Other 18 16%
Unknown 21 19%
Readers by discipline Count As %
Neuroscience 23 21%
Agricultural and Biological Sciences 22 20%
Medicine and Dentistry 19 17%
Biochemistry, Genetics and Molecular Biology 10 9%
Psychology 3 3%
Other 9 8%
Unknown 26 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2013.
All research outputs
#16,140,120
of 24,549,201 outputs
Outputs from Brain Pathology
#896
of 1,197 outputs
Outputs of similar age
#131,133
of 218,527 outputs
Outputs of similar age from Brain Pathology
#4
of 6 outputs
Altmetric has tracked 24,549,201 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,197 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 218,527 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.