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Neural Correlates of Alcohol-Approach Bias in Alcohol Addiction: the Spirit is Willing but the Flesh is Weak for Spirits

Overview of attention for article published in Neuropsychopharmacology, September 2013
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Title
Neural Correlates of Alcohol-Approach Bias in Alcohol Addiction: the Spirit is Willing but the Flesh is Weak for Spirits
Published in
Neuropsychopharmacology, September 2013
DOI 10.1038/npp.2013.252
Pubmed ID
Authors

Corinde E Wiers, Christine Stelzel, Soyoung Q Park, Christiane K Gawron, Vera U Ludwig, Stefan Gutwinski, Andreas Heinz, Johannes Lindenmeyer, Reinout W Wiers, Henrik Walter, Felix Bermpohl

Abstract

Behavioral studies have shown an alcohol-approach bias in alcohol-dependent patients: the automatic tendency to faster approach than avoid alcohol compared with neutral cues, which has been associated with craving and relapse. Although this is a well-studied psychological phenomenon, little is known about the brain processes underlying automatic action tendencies in addiction. We examined 20 alcohol-dependent patients and 17 healthy controls with functional magnetic resonance imaging (fMRI), while performing an implicit approach-avoidance task. Participants pushed and pulled pictorial cues of alcohol and soft-drink beverages, according to a content-irrelevant feature of the cue (landscape/portrait). The critical fMRI contrast regarding the alcohol-approach bias was defined as (approach alcohol>avoid alcohol)>(approach soft drink>avoid soft drink). This was reversed for the avoid-alcohol contrast: (avoid alcohol>approach alcohol)>(avoid soft drink>approach soft drink). In comparison with healthy controls, alcohol-dependent patients had stronger behavioral approach tendencies for alcohol cues than for soft-drink cues. In the approach, alcohol fMRI contrast patients showed larger blood-oxygen-level-dependent responses in the nucleus accumbens and medial prefrontal cortex, regions involved in reward and motivational processing. In alcohol-dependent patients, alcohol-craving scores were positively correlated with activity in the amygdala for the approach-alcohol contrast. The dorsolateral prefrontal cortex was not activated in the avoid-alcohol contrast in patients vs controls. Our data suggest that brain regions that have a key role in reward and motivation are associated with the automatic alcohol-approach bias in alcohol-dependent patients.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 204 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 4 2%
Iran, Islamic Republic of 2 <1%
South Africa 1 <1%
Netherlands 1 <1%
United Kingdom 1 <1%
United States 1 <1%
Unknown 194 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 43 21%
Student > Master 36 18%
Researcher 34 17%
Student > Bachelor 13 6%
Student > Doctoral Student 11 5%
Other 30 15%
Unknown 37 18%
Readers by discipline Count As %
Psychology 90 44%
Neuroscience 18 9%
Medicine and Dentistry 18 9%
Agricultural and Biological Sciences 11 5%
Social Sciences 5 2%
Other 14 7%
Unknown 48 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2014.
All research outputs
#14,177,917
of 22,723,682 outputs
Outputs from Neuropsychopharmacology
#3,341
of 4,103 outputs
Outputs of similar age
#112,625
of 201,793 outputs
Outputs of similar age from Neuropsychopharmacology
#38
of 67 outputs
Altmetric has tracked 22,723,682 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,103 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.9. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
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We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.