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Solution NMR structure of CD1104B from pathogenic Clostridium difficile reveals a distinct α-helical architecture and provides first structural representative of protein domain family PF14203

Overview of attention for article published in Journal of Structural and Functional Genomics, September 2013
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Title
Solution NMR structure of CD1104B from pathogenic Clostridium difficile reveals a distinct α-helical architecture and provides first structural representative of protein domain family PF14203
Published in
Journal of Structural and Functional Genomics, September 2013
DOI 10.1007/s10969-013-9164-8
Pubmed ID
Authors

Surya V. S. R. K. Pulavarti, Alexander Eletsky, Hsiau-Wei Lee, Thomas B. Acton, Rong Xiao, John K. Everett, James H. Prestegard, Gaetano T. Montelione, Thomas Szyperski

Abstract

A high-quality structure of the 68-residue protein CD1104B from Clostridium difficile strain 630 exhibits a distinct all α-helical fold. The structure presented here is the first representative of bacterial protein domain family PF14203 (currently 180 members) of unknown function (DUF4319) and reveals that the side-chains of the only two strictly conserved residues (Glu 8 and Lys 48) form a salt bridge. Moreover, these two residues are located in the vicinity of the largest surface cleft which is predicted to contribute to a surface area involved in protein-protein interactions. This, along with its coding in transposon CTn4, suggests that CD1104B (and very likely all members of Pfam 14203) functions by interacting with other proteins required for the transfer of transposons between different bacterial species.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 20%
Professor > Associate Professor 2 20%
Professor 1 10%
Researcher 1 10%
Student > Bachelor 1 10%
Other 0 0%
Unknown 3 30%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 1 10%
Agricultural and Biological Sciences 1 10%
Immunology and Microbiology 1 10%
Physics and Astronomy 1 10%
Earth and Planetary Sciences 1 10%
Other 2 20%
Unknown 3 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 September 2013.
All research outputs
#20,203,867
of 22,723,682 outputs
Outputs from Journal of Structural and Functional Genomics
#97
of 107 outputs
Outputs of similar age
#176,676
of 201,864 outputs
Outputs of similar age from Journal of Structural and Functional Genomics
#2
of 2 outputs
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So far Altmetric has tracked 107 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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