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Different subsets of newborn granule cells: a possible role in epileptogenesis?

Overview of attention for article published in European Journal of Neuroscience, October 2013
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Title
Different subsets of newborn granule cells: a possible role in epileptogenesis?
Published in
European Journal of Neuroscience, October 2013
DOI 10.1111/ejn.12387
Pubmed ID
Authors

Pascal Bielefeld, Erwin A. van Vliet, Jan A. Gorter, Paul J. Lucassen, Carlos P. Fitzsimons

Abstract

Several factors, including epileptic seizures, can strongly stimulate ongoing neurogenesis in the adult hippocampus. Although adult-born granule cells generated after seizure activity have different physiological properties from their normal counterparts, they integrate into the existing, mature network of the adult hippocampal dentate gyrus. However, the exact role of the neurogenic response during epilepsy and its possible involvement in epileptogenesis have remained elusive. Here, we discuss recent studies shedding new light on the interplay between epilepsy and neurogenesis, and try to explain discrepancies in this literature by proposing seizure severity-dependent induction of two subsets of newborn cells with different properties. We hypothesise that a low seizure intensity would stimulate neurogenesis to a 'physiological plasticity' level and have few pathological consequences. In contrast, a high initial seizure intensity may induce a specific subset of altered and/or ectopically located new granule cells with different electrophysiological properties that could initiate hyperexcitatory recurrent networks that could, in turn, contribute to chronic epilepsy. This hypothesis may clarify previously contradictory data in the literature, and could thereby aid in our understanding of the role of neurogenesis in epileptogenesis, and open up promising avenues for therapeutic intervention.

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The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
United States 1 1%
Germany 1 1%
Canada 1 1%
Unknown 71 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 15 20%
Researcher 14 19%
Student > Ph. D. Student 14 19%
Student > Bachelor 8 11%
Student > Doctoral Student 7 9%
Other 12 16%
Unknown 5 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 31%
Neuroscience 23 31%
Medicine and Dentistry 15 20%
Biochemistry, Genetics and Molecular Biology 2 3%
Nursing and Health Professions 2 3%
Other 3 4%
Unknown 7 9%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2014.
All research outputs
#14,566,885
of 24,558,777 outputs
Outputs from European Journal of Neuroscience
#4,023
of 6,057 outputs
Outputs of similar age
#115,570
of 216,501 outputs
Outputs of similar age from European Journal of Neuroscience
#26
of 78 outputs
Altmetric has tracked 24,558,777 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,057 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 216,501 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.