↓ Skip to main content

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

Overview of attention for article published in Science, November 2013
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Citations

dimensions_citation
788 Dimensions

Readers on

mendeley
543 Mendeley
citeulike
2 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus
Published in
Science, November 2013
DOI 10.1126/science.1243283
Pubmed ID
Authors

Jason S. McLellan, Man Chen, M. Gordon Joyce, Mallika Sastry, Guillaume B. E. Stewart-Jones, Yongping Yang, Baoshan Zhang, Lei Chen, Sanjay Srivatsan, Anqi Zheng, Tongqing Zhou, Kevin W. Graepel, Azad Kumar, Syed Moin, Jeffrey C. Boyington, Gwo-Yu Chuang, Cinque Soto, Ulrich Baxa, Arjen Q. Bakker, Hergen Spits, Tim Beaumont, Zizheng Zheng, Ningshao Xia, Sung-Youl Ko, John-Paul Todd, Srinivas Rao, Barney S. Graham, Peter D. Kwong

Abstract

Respiratory syncytial virus (RSV) is the leading cause of hospitalization for children under 5 years of age. We sought to engineer a viral antigen that provides greater protection than currently available vaccines and focused on antigenic site Ø, a metastable site specific to the prefusion state of the RSV fusion (F) glycoprotein, as this site is targeted by extremely potent RSV-neutralizing antibodies. Structure-based design yielded stabilized versions of RSV F that maintained antigenic site Ø when exposed to extremes of pH, osmolality, and temperature. Six RSV F crystal structures provided atomic-level data on how introduced cysteine residues and filled hydrophobic cavities improved stability. Immunization with site Ø-stabilized variants of RSV F in mice and macaques elicited levels of RSV-specific neutralizing activity many times the protective threshold.

X Demographics

X Demographics

The data shown below were collected from the profiles of 74 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 543 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 1%
United Kingdom 4 <1%
Japan 3 <1%
Ireland 1 <1%
Israel 1 <1%
Netherlands 1 <1%
Taiwan 1 <1%
Colombia 1 <1%
Germany 1 <1%
Other 1 <1%
Unknown 523 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 137 25%
Researcher 115 21%
Student > Master 48 9%
Student > Bachelor 39 7%
Student > Doctoral Student 25 5%
Other 74 14%
Unknown 105 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 140 26%
Biochemistry, Genetics and Molecular Biology 107 20%
Immunology and Microbiology 63 12%
Medicine and Dentistry 46 8%
Chemistry 21 4%
Other 51 9%
Unknown 115 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 615. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 March 2024.
All research outputs
#36,925
of 25,591,967 outputs
Outputs from Science
#1,553
of 83,123 outputs
Outputs of similar age
#198
of 227,101 outputs
Outputs of similar age from Science
#16
of 888 outputs
Altmetric has tracked 25,591,967 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,123 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.8. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,101 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 888 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.