Title |
NMDA Receptor Antagonist Ketamine Impairs Feature Integration in Visual Perception
|
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Published in |
PLOS ONE, November 2013
|
DOI | 10.1371/journal.pone.0079326 |
Pubmed ID | |
Authors |
Julia D. I. Meuwese, Anouk M. van Loon, H. Steven Scholte, Philipp B. Lirk, Nienke C. C. Vulink, Markus W. Hollmann, Victor A. F. Lamme |
Abstract |
Recurrent interactions between neurons in the visual cortex are crucial for the integration of image elements into coherent objects, such as in figure-ground segregation of textured images. Blocking N-methyl-D-aspartate (NMDA) receptors in monkeys can abolish neural signals related to figure-ground segregation and feature integration. However, it is unknown whether this also affects perceptual integration itself. Therefore, we tested whether ketamine, a non-competitive NMDA receptor antagonist, reduces feature integration in humans. We administered a subanesthetic dose of ketamine to healthy subjects who performed a texture discrimination task in a placebo-controlled double blind within-subject design. We found that ketamine significantly impaired performance on the texture discrimination task compared to the placebo condition, while performance on a control fixation task was much less impaired. This effect is not merely due to task difficulty or a difference in sedation levels. We are the first to show a behavioral effect on feature integration by manipulating the NMDA receptor in humans. |
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Mendeley readers
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Unknown | 60 | 91% |
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Student > Ph. D. Student | 13 | 20% |
Student > Master | 13 | 20% |
Researcher | 6 | 9% |
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Professor > Associate Professor | 5 | 8% |
Other | 13 | 20% |
Unknown | 10 | 15% |
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Arts and Humanities | 3 | 5% |
Other | 3 | 5% |
Unknown | 11 | 17% |