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Attention Score in Context
| Title |
Occupancy of serotonin transporters in the amygdala by paroxetine in association with attenuation of left amygdala activation by negative faces in major depressive disorder
|
|---|---|
| Published in |
Psychiatry Research, December 2013
|
| DOI | 10.1016/j.pscychresns.2013.12.003 |
| Pubmed ID | |
| Authors |
Henricus G. Ruhé, Michiel Koster, Jan Booij, Marcel van Herk, Dick J. Veltman, Aart H. Schene |
| Abstract |
Amygdala hyperactivation in major depressive disorder (MDD) might be attenuated by selective serotonin reuptake inhibitors (SSRIs), but the working mechanism remains unclear. We hypothesized that higher amygdala serotonin transporter (SERT) occupancy by paroxetine results in greater attenuation of amygdala activation by negative facial expressions in MDD patients. We treated fifteen MDD patients (22-55 years) with paroxetine 20-50mg/day. After 6 and 12 weeks, we quantified (1) clinical response (≥50% decrease in Hamilton Depression Rating Scale (HDRS), (2) SERT occupancy in both amygdala measured by repeated [123I]β-CIT single photon emission computed tomography (SPECT), and (3) amygdala activation when viewing fearful and angry (negative) faces with repeated functional MRI scans. Response rates were 4/15 and 9/15 at 6 and 12 weeks, respectively. Attenuation of left amygdala activation was associated with amygdala SERT occupancy (P=0.006) and response (P=0.015). This association may provide a rationale for decreased limbic activity seen during treatment of MDD. It might also explain the rapid decrease in negative attentional bias and amygdala activation caused by SSRIs. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Egypt | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 66 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 32% |
| Student > Bachelor | 10 | 15% |
| Researcher | 6 | 9% |
| Student > Master | 6 | 9% |
| Other | 5 | 8% |
| Other | 11 | 17% |
| Unknown | 7 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 23 | 35% |
| Medicine and Dentistry | 17 | 26% |
| Neuroscience | 5 | 8% |
| Agricultural and Biological Sciences | 3 | 5% |
| Physics and Astronomy | 2 | 3% |
| Other | 2 | 3% |
| Unknown | 14 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 January 2014.
All research outputs
#16,045,990
of 25,371,288 outputs
Outputs from Psychiatry Research
#4,238
of 7,587 outputs
Outputs of similar age
#188,613
of 320,491 outputs
Outputs of similar age from Psychiatry Research
#68
of 149 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,587 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,491 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 149 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.