Title |
Ménage à trois: Borrelia, dendritic cells, and tick saliva interactions
|
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Published in |
Trends in Parasitology, December 2013
|
DOI | 10.1016/j.pt.2013.12.003 |
Pubmed ID | |
Authors |
Lauren M.K. Mason, Christiaan C. Veerman, Teunis B.H. Geijtenbeek, Joppe W.R. Hovius |
Abstract |
Borrelia burgdorferi sensu lato, the causative agent of Lyme borreliosis, is inoculated into the skin during an Ixodes tick bite where it is recognised and captured by dendritic cells (DCs). However, considering the propensity of Borrelia to disseminate, it would appear that DCs fall short in mounting a robust immune response against it. Many aspects of the DC-driven immune response to Borrelia have been examined. Recently, components of tick saliva have been identified that sabotage DC responses and aid Borrelia infection. In this review, we summarise what is currently known about the immune response of DCs to Borrelia and explore the mechanisms by which Borrelia manages to circumvent this immune response, with or without the help of tick salivary proteins. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 13% |
France | 1 | 13% |
United Kingdom | 1 | 13% |
Canada | 1 | 13% |
Unknown | 4 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 50% |
Practitioners (doctors, other healthcare professionals) | 2 | 25% |
Scientists | 1 | 13% |
Science communicators (journalists, bloggers, editors) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Russia | 2 | 3% |
United Kingdom | 1 | 1% |
Portugal | 1 | 1% |
Mexico | 1 | 1% |
United States | 1 | 1% |
Unknown | 73 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 14% |
Student > Master | 11 | 14% |
Researcher | 10 | 13% |
Student > Bachelor | 8 | 10% |
Professor | 7 | 9% |
Other | 18 | 23% |
Unknown | 14 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 25 | 32% |
Medicine and Dentistry | 13 | 16% |
Immunology and Microbiology | 10 | 13% |
Biochemistry, Genetics and Molecular Biology | 8 | 10% |
Veterinary Science and Veterinary Medicine | 3 | 4% |
Other | 5 | 6% |
Unknown | 15 | 19% |