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Reduced Frontal Brain Volume in Non-Treatment-Seeking Cocaine-Dependent Individuals: Exploring the Role of Impulsivity, Depression, and Smoking

Overview of attention for article published in Frontiers in Human Neuroscience, January 2014
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Title
Reduced Frontal Brain Volume in Non-Treatment-Seeking Cocaine-Dependent Individuals: Exploring the Role of Impulsivity, Depression, and Smoking
Published in
Frontiers in Human Neuroscience, January 2014
DOI 10.3389/fnhum.2014.00007
Pubmed ID
Authors

Cleo L. Crunelle, Anne Marije Kaag, Guido van Wingen, Hanna E. van den Munkhof, Judith R. Homberg, Liesbeth Reneman, Wim van den Brink

Abstract

In cocaine-dependent patients, gray matter (GM) volume reductions have been observed in the frontal lobes that are associated with the duration of cocaine use. Studies are mostly restricted to treatment-seekers and studies in non-treatment-seeking cocaine abusers are sparse. Here, we assessed GM volume differences between 30 non-treatment-seeking cocaine-dependent individuals and 33 non-drug using controls using voxel-based morphometry. Additionally, within the group of non-treatment-seeking cocaine-dependent individuals, we explored the role of frequently co-occurring features such as trait impulsivity (Barratt Impulsivity Scale, BIS), smoking, and depressive symptoms (Beck Depression Inventory), as well as the role of cocaine use duration, on frontal GM volume. Smaller GM volumes in non-treatment-seeking cocaine-dependent individuals were observed in the left middle frontal gyrus. Moreover, within the group of cocaine users, trait impulsivity was associated with reduced GM volume in the right orbitofrontal cortex, the left precentral gyrus, and the right superior frontal gyrus, whereas no effect of smoking severity, depressive symptoms, or duration of cocaine use was observed on regional GM volumes. Our data show an important association between trait impulsivity and frontal GM volumes in cocaine-dependent individuals. In contrast to previous studies with treatment-seeking cocaine-dependent patients, no significant effects of smoking severity, depressive symptoms, or duration of cocaine use on frontal GM volume were observed. Reduced frontal GM volumes in non-treatment-seeking cocaine-dependent subjects are associated with trait impulsivity and are not associated with co-occurring nicotine dependence or depression.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Hong Kong 1 1%
Israel 1 1%
Netherlands 1 1%
Brazil 1 1%
Unknown 66 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 29%
Student > Master 7 10%
Student > Bachelor 7 10%
Researcher 6 9%
Other 5 7%
Other 10 14%
Unknown 15 21%
Readers by discipline Count As %
Psychology 18 26%
Neuroscience 11 16%
Engineering 5 7%
Medicine and Dentistry 5 7%
Agricultural and Biological Sciences 3 4%
Other 6 9%
Unknown 22 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 January 2014.
All research outputs
#18,360,179
of 22,739,983 outputs
Outputs from Frontiers in Human Neuroscience
#6,056
of 7,136 outputs
Outputs of similar age
#229,327
of 305,211 outputs
Outputs of similar age from Frontiers in Human Neuroscience
#105
of 122 outputs
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