You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Jaspine B induces nonapoptotic cell death in gastric cancer cells independently of its inhibition of ceramide synthase
|
|---|---|
| Published in |
Journal of Lipid Research, June 2017
|
| DOI | 10.1194/jlr.m072611 |
| Pubmed ID | |
| Authors |
Francesca Cingolani, Fabio Simbari, Jose Luis Abad, Mireia Casasampere, Gemma Fabrias, Anthony H Futerman, Josefina Casas |
| Abstract |
Sphingolipids have been extensively investigated in biomedical research due to their role as bioactive molecules in cells. Here we describe the effect of a sphingolipid analogue, Jaspine B (JB), a cyclic anhydrophytosphingosine found in marine sponges, on the gastric cancer cell line HGC-27. JB induces alterations in the sphingolipidome, mainly the accumulation of dihydrosphingosine (dhSo) and sphingosine (So), and their phosphorylated forms, due to inhibition of ceramide synthases (CerS). Moreover, JB induces atypical cell death in HGC-27 cells, characterized by the formation of cytoplasmic vacuoles in a time and dose-dependent manner. Vacuoles appear to originate from macropinocytosis and trigger cytoplasmic disruption. The pan-caspase inhibitor Z-VAD does not alter either cytotoxicity or vacuole formation, suggesting that JB activates a caspase-independent cell death mechanism. The autophagy inhibitor wortmannin did not decrease JB-stimulated LC3 II accumulation. In addition, cell vacuolation induced by JB is characterised by single-membrane vacuoles which are different from double-membrane autophagosomes. These findings suggest that JB-induced cell vacuolation is not related to autophagy and it is also independent of its action on sphingolipid metabolism. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 28 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 4 | 14% |
| Professor | 4 | 14% |
| Student > Bachelor | 4 | 14% |
| Student > Postgraduate | 3 | 11% |
| Unspecified | 2 | 7% |
| Other | 7 | 25% |
| Unknown | 4 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 9 | 32% |
| Chemistry | 5 | 18% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
| Unspecified | 2 | 7% |
| Agricultural and Biological Sciences | 2 | 7% |
| Other | 1 | 4% |
| Unknown | 7 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2024.
All research outputs
#7,921,971
of 25,744,802 outputs
Outputs from Journal of Lipid Research
#1,846
of 4,836 outputs
Outputs of similar age
#115,650
of 331,552 outputs
Outputs of similar age from Journal of Lipid Research
#13
of 39 outputs
Altmetric has tracked 25,744,802 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 4,836 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,552 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.