Title |
MicroRNA-34c is associated with emphysema severity and modulates SERPINE1 expression
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Published in |
BMC Genomics, January 2014
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DOI | 10.1186/1471-2164-15-88 |
Pubmed ID | |
Authors |
Santiyagu M Savarimuthu Francis, Morgan R Davidson, Maxine E Tan, Casey M Wright, Belinda E Clarke, Edwina E Duhig, Rayleen V Bowman, Nicholas K Hayward, Kwun M Fong, Ian A Yang |
Abstract |
MicroRNAs (MiRNA) are small non-coding RNAs that regulate gene expression. The aim of this study was to identify miRNAs differentially expressed between mild and moderately emphysematous lung, as well as their functional target mRNAs. Resected lung from patients with COPD undergoing lung cancer surgery was profiled using miRNA (Agilent Human miRNA profiler G4470 V1.01) and mRNA (OperonV2.0) microarrays. Cells of lung origin (BEAS-2B and HFL1) were profiled using mRNA microarrays (Illumina HumanHT-12 V3) after in vitro manipulation. |
X Demographics
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Mexico | 1 | 33% |
France | 1 | 33% |
Australia | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 2% |
Unknown | 41 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 13 | 31% |
Researcher | 7 | 17% |
Student > Master | 6 | 14% |
Student > Bachelor | 4 | 10% |
Student > Doctoral Student | 1 | 2% |
Other | 4 | 10% |
Unknown | 7 | 17% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 10 | 24% |
Nursing and Health Professions | 3 | 7% |
Medicine and Dentistry | 3 | 7% |
Physics and Astronomy | 2 | 5% |
Other | 4 | 10% |
Unknown | 9 | 21% |