Title |
Lectin of Abelmoschus esculentus (okra) promotes selective antitumor effects in human breast cancer cells
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Published in |
Biotechnology Techniques, October 2013
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DOI | 10.1007/s10529-013-1382-4 |
Pubmed ID | |
Authors |
Leonardo G. Monte, Tatiane Santi-Gadelha, Larissa B. Reis, Elizandra Braganhol, Rafael F. Prietsch, Odir A. Dellagostin, Rodrigo Rodrigues e Lacerda, Carlos A. A. Gadelha, Fabricio R. Conceição, Luciano S. Pinto |
Abstract |
The anti-tumor effects of a newly-discovered lectin, isolated from okra, Abelmoschus esculentus (AEL), were investigated in human breast cancer (MCF7) and skin fibroblast (CCD-1059 sk) cells. AEL induced significant cell growth inhibition (63 %) in MCF7 cells. The expression of pro-apoptotic caspase-3, caspase-9, and p21 genes was increased in MCF7 cells treated with AEL, compared to those treated with controls. In addition, AEL treatment increased the Bax/Bcl-2 ratio in MCF7 cells. Flow cytometry also indicated that cell death (72 %) predominantly occurred through apoptosis. Thus, AEL in its native form promotes selective antitumor effects in human breast cancer cells and may represent a potential therapeutic to combat human breast cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 5 | 21% |
United Kingdom | 4 | 17% |
Germany | 1 | 4% |
New Zealand | 1 | 4% |
Uganda | 1 | 4% |
Unknown | 12 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 22 | 92% |
Science communicators (journalists, bloggers, editors) | 1 | 4% |
Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 93 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 14 | 15% |
Student > Bachelor | 12 | 13% |
Researcher | 11 | 12% |
Student > Ph. D. Student | 8 | 8% |
Professor | 4 | 4% |
Other | 14 | 15% |
Unknown | 32 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 20 | 21% |
Biochemistry, Genetics and Molecular Biology | 15 | 16% |
Chemistry | 6 | 6% |
Medicine and Dentistry | 5 | 5% |
Computer Science | 4 | 4% |
Other | 9 | 9% |
Unknown | 36 | 38% |