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Mendeley readers
Attention Score in Context
| Title |
Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human HL-60 promyelocytic leukemia cells
|
|---|---|
| Published in |
Cancer Letters, November 2006
|
| DOI | 10.1016/j.canlet.2006.10.018 |
| Pubmed ID | |
| Authors |
Philipp Saiko, Maria Ozsvar-Kozma, Sibylle Madlener, Astrid Bernhaus, Andreas Lackner, Michael Grusch, Zsuzsanna Horvath, Georg Krupitza, Walter Jaeger, Kirsten Ammer, Monika Fritzer-Szekeres, Thomas Szekeres |
| Abstract |
Avemar (MSC) is a nontoxic fermented wheat germ extract demonstrated to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in human HL-60 promyelocytic leukemia cells. After 24, 48, and 72 h of incubation, Avemar inhibited the growth of HL-60 cells with IC50 values of 400, 190, and 160 microg/ml, respectively. Incubation with MSC caused dose-dependent induction of apoptosis in up to 85% of tumor cells. In addition, Avemar attenuated the progression from G2-M to G0-G1 phase of the cell cycle and was also found to significantly reduce the in situ activity of ribonucleotide reductase, the key enzyme of de novo DNA synthesis. We conclude that Avemar exerts a number of beneficial effects which could support conventional chemotherapy of human malignancies. |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 4% |
| Poland | 1 | 4% |
| Unknown | 21 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 5 | 22% |
| Researcher | 5 | 22% |
| Professor > Associate Professor | 3 | 13% |
| Student > Ph. D. Student | 2 | 9% |
| Student > Master | 2 | 9% |
| Other | 1 | 4% |
| Unknown | 5 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 26% |
| Agricultural and Biological Sciences | 5 | 22% |
| Biochemistry, Genetics and Molecular Biology | 2 | 9% |
| Immunology and Microbiology | 2 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 9% |
| Other | 0 | 0% |
| Unknown | 6 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 March 2014.
All research outputs
#6,736,990
of 25,374,917 outputs
Outputs from Cancer Letters
#1,540
of 6,178 outputs
Outputs of similar age
#35,034
of 168,388 outputs
Outputs of similar age from Cancer Letters
#12
of 34 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 6,178 research outputs from this source. They receive a mean Attention Score of 4.6. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 168,388 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.