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HIV Type 1 Transmission Networks Among Men Having Sex with Men and Heterosexuals in Kenya

Overview of attention for article published in AIDS Research and Human Retroviruses, September 2013
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Title
HIV Type 1 Transmission Networks Among Men Having Sex with Men and Heterosexuals in Kenya
Published in
AIDS Research and Human Retroviruses, September 2013
DOI 10.1089/aid.2013.0171
Pubmed ID
Authors

Daniela Bezemer, Nuno Rodrigues Faria, Amin Hassan, Raph L. Hamers, Gaudensia Mutua, Omu Anzala, Kishor Mandaliya, Patricia Cane, James A. Berkley, Tobias F. Rinke de Wit, Carole Wallis, Susan M. Graham, Matthew A. Price, Roel A. Coutinho, Eduard J. Sanders

Abstract

We performed a molecular phylogenetic study on HIV-1 polymerase sequences of men who have sex with men (MSM) and heterosexual patient samples in Kenya to characterize any observed HIV-1 transmission networks. HIV-1 polymerase sequences were obtained from samples in Nairobi and coastal Kenya from 84 MSM, 226 other men, and 364 women from 2005 to 2010. Using Bayesian phylogenetics, we tested whether sequences clustered by sexual orientation and geographic location. In addition, we used trait diffusion analyses to identify significant epidemiological links and to quantify the number of transmissions between risk groups. Finally, we compared 84 MSM sequences with all HIV-1 sequences available online at GenBank. Significant clustering of sequences from MSM at both coastal Kenya and Nairobi was found, with evidence of HIV-1 transmission between both locations. Although a transmission pair between a coastal MSM and woman was confirmed, no significant HIV-1 transmission was evident between MSM and the comparison population for the predominant subtype A (60%). However, a weak but significant link was evident when studying all subtypes together. GenBank comparison did not reveal other important transmission links. Our data suggest infrequent intermingling of MSM and heterosexual HIV-1 epidemics in Kenya.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 94 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 21 22%
Student > Master 18 19%
Student > Ph. D. Student 12 13%
Student > Bachelor 8 8%
Student > Doctoral Student 7 7%
Other 15 16%
Unknown 14 15%
Readers by discipline Count As %
Medicine and Dentistry 30 32%
Agricultural and Biological Sciences 12 13%
Social Sciences 10 11%
Biochemistry, Genetics and Molecular Biology 7 7%
Nursing and Health Professions 4 4%
Other 14 15%
Unknown 18 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 March 2014.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from AIDS Research and Human Retroviruses
#2,273
of 2,499 outputs
Outputs of similar age
#189,381
of 213,541 outputs
Outputs of similar age from AIDS Research and Human Retroviruses
#19
of 25 outputs
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