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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Wnt Signaling and the Control of Human Stem Cell Fate
|
|---|---|
| Published in |
Stem Cell Reviews and Reports, December 2013
|
| DOI | 10.1007/s12015-013-9486-8 |
| Pubmed ID | |
| Authors |
J. K. Van Camp, S. Beckers, D. Zegers, W. Van Hul |
| Abstract |
Wnt signaling determines major developmental processes in the embryonic state and regulates maintenance, self-renewal and differentiation of adult mammalian tissue stem cells. Both β-catenin dependent and independent Wnt pathways exist, and both affect stem cell fate in developing and adult tissues. In this review, we debate the response to Wnt signal activation in embryonic stem cells and human, adult stem cells of mesenchymal, hematopoetic, intestinal, gastric, epidermal, mammary and neural lineages, and discuss the need for Wnt signaling in these cell types. Due to the vital actions of Wnt signaling in developmental and maintenance processes, deregulation of the pathway can culminate into a broad spectrum of developmental and genetic diseases, including cancer. The way in which Wnt signals can feed tumors and maintain cancer stem stells is discussed as well. Manipulation of Wnt signals both in vivo and in vitro thus carries potential for therapeutic approaches such as tissue engineering for regenerative medicine and anti-cancer treatment. Although many questions remain regarding the complete Wnt signal cell-type specific response and interplay of Wnt signaling with pathways such as BMP, Hedgehog and Notch, we hereby provide an overview of current knowledge on Wnt signaling and its control over human stem cell fate. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 223 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 1% |
| Turkey | 1 | <1% |
| Germany | 1 | <1% |
| United Kingdom | 1 | <1% |
| Serbia | 1 | <1% |
| Unknown | 216 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 59 | 26% |
| Student > Master | 30 | 13% |
| Researcher | 26 | 12% |
| Student > Bachelor | 25 | 11% |
| Student > Doctoral Student | 15 | 7% |
| Other | 23 | 10% |
| Unknown | 45 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 62 | 28% |
| Biochemistry, Genetics and Molecular Biology | 51 | 23% |
| Medicine and Dentistry | 24 | 11% |
| Neuroscience | 8 | 4% |
| Engineering | 6 | 3% |
| Other | 24 | 11% |
| Unknown | 48 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 April 2022.
All research outputs
#5,165,601
of 25,373,627 outputs
Outputs from Stem Cell Reviews and Reports
#191
of 1,035 outputs
Outputs of similar age
#56,792
of 320,161 outputs
Outputs of similar age from Stem Cell Reviews and Reports
#3
of 8 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,035 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,161 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.