Clostridium difficile phages: still difficult?

Overview of attention for article published in Frontiers in Microbiology, April 2014
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  • In the top 5% of all articles scored by Altmetric
  • High score compared to articles of the same age (92nd percentile)
  • High score compared to articles of the same age and source (96th percentile)

Mentioned by

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18 tweeters
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1 Wikipedia page
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1 Google+ user

Readers on

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14 Mendeley
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Article title
Clostridium difficile phages: still difficult?
Published in
Frontiers in Microbiology, April 2014
DOI 10.3389/fmicb.2014.00184
Pubmed ID
Authors

Hargreaves, Katherine Rose, Clokie, Martha Rebecca Jane

Abstract

Phages that infect Clostridium difficile were first isolated for typing purposes in the 1980s, but their use was short lived. However, the rise of C. difficile epidemics over the last decade has triggered a resurgence of interest in using phages to combat this pathogen. Phage therapy is an attractive treatment option for C. difficile infection, however, developing suitable phages is challenging. In this review we summarize the difficulties faced by researchers in this field, and we discuss the solutions and strategies used for the development of C. difficile phages for use as novel therapeutics. Epidemiological data has highlighted the diversity and distribution of C. difficile, and shown that novel strains continue to emerge in clinical settings. In parallel with epidemiological studies, advances in molecular biology have bolstered our understanding of C. difficile biology, and our knowledge of phage-host interactions in other bacterial species. These three fields of biology have therefore paved the way for future work on C. difficile phages to progress and develop. Benefits of using C. difficile phages as therapeutic agents include the fact that they have highly specific interactions with their bacterial hosts. Studies also show that they can reduce bacterial numbers in both in vitro and in vivo systems. Genetic analysis has revealed the genomic diversity among these phages and provided an insight into their taxonomy and evolution. No strictly virulent C. difficile phages have been reported and this contributes to the difficulties with their therapeutic exploitation. Although treatment approaches using the phage-encoded endolysin protein have been explored, the benefits of using "whole-phages" are such that they remain a major research focus. Whilst we don't envisage working with C. difficile phages will be problem-free, sufficient study should inform future strategies to facilitate their development to combat this problematic pathogen.

Twitter Demographics

The data shown below were collected from the profiles of 18 tweeters who shared this article. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this article. Click here to see the article's page on the Mendeley website.

Geographical breakdown

Country Count As %
United States 1 7%
Unknown 13 93%

Demographic breakdown

Readers by professional status Count As %
Ph.D. Student 9 64%
Assistant Professor 2 14%
Doctoral Student 1 7%
Student (Master) 1 7%
Researcher (at a non-Academic Institution) 1 7%
Other 0 0%
Readers by discipline Count As %
Biological Sciences 13 93%
Medicine 1 7%

Score in context

This article has an Altmetric score of 15.55. This is our high-level measure of the quality and quantity of online attention that this article has received. This score was calculated when the article was last mentioned on 24 November 2014.
All articles
#185,997
of 3,790,511 articles
Articles in Frontiers in Microbiology
#54
of 1,664 articles
Articles of similar age
#7,405
of 98,240 articles
Articles of similar age in Frontiers in Microbiology
#2
of 54 articles
Altmetric has tracked 3,790,511 articles across all sources so far. Compared to these this article has done particularly well and is in the 95th percentile: it's in the top 5% of all articles ever tracked by Altmetric.
So far Altmetric has tracked 1,664 articles from this source. They typically receive a little less attention than average, with a mean score of 3.5. This article has done particularly well, scoring higher than 96% of its peers.
Older articles will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this score to the 98,240 tracked articles that were published within six weeks on either side of this one in any source. This article has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this article to 54 articles from the same source and published within six weeks on either side of this one. This article has done particularly well, scoring higher than 96% of its contemporaries.