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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A C1-C2 Module in Munc13 Inhibits Calcium-Dependent Neurotransmitter Release
|
|---|---|
| Published in |
Neuron, August 2017
|
| DOI | 10.1016/j.neuron.2017.07.015 |
| Pubmed ID | |
| Authors |
Francesco Michelassi, Haowen Liu, Zhitao Hu, Jeremy S. Dittman |
| Abstract |
Almost all known forms of fast chemical synaptic transmission require the synaptic hub protein Munc13. This essential protein has also been implicated in mediating several forms of use-dependent plasticity, but the mechanisms by which it controls vesicle fusion and plasticity are not well understood. Using the C. elegans Munc13 ortholog UNC-13, we show that deletion of the C2B domain, the most highly conserved domain of Munc13, enhances calcium-dependent exocytosis downstream of vesicle priming, revealing a novel autoinhibitory role for the C2B. Furthermore, C2B inhibition is relieved by calcium binding to C2B, while the neighboring C1 domain acts together with C2B to stabilize the autoinhibited state. Selective disruption of Munc13 autoinhibition profoundly impacts nervous system function in vivo. Thus, C1-C2B exerts a basal inhibition on Munc13 in the primed state, permitting calcium- and lipid-dependent control of C1-C2B to modulate synaptic strength. |
X Demographics
The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 33% |
| United Kingdom | 2 | 17% |
| France | 1 | 8% |
| Puerto Rico | 1 | 8% |
| Australia | 1 | 8% |
| Unknown | 3 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 58% |
| Scientists | 4 | 33% |
| Science communicators (journalists, bloggers, editors) | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 78 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 26% |
| Researcher | 16 | 21% |
| Student > Bachelor | 4 | 5% |
| Student > Doctoral Student | 3 | 4% |
| Other | 3 | 4% |
| Other | 11 | 14% |
| Unknown | 21 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 23 | 29% |
| Agricultural and Biological Sciences | 16 | 21% |
| Biochemistry, Genetics and Molecular Biology | 14 | 18% |
| Medicine and Dentistry | 2 | 3% |
| Environmental Science | 1 | 1% |
| Other | 1 | 1% |
| Unknown | 21 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 August 2021.
All research outputs
#2,434,101
of 25,382,440 outputs
Outputs from Neuron
#3,428
of 9,546 outputs
Outputs of similar age
#44,790
of 327,503 outputs
Outputs of similar age from Neuron
#93
of 146 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,546 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.2. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,503 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 146 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.