Folding graft copolymer with pendant drug segments for co-delivery of anticancer drugs.

Overview of attention for article published in Biomaterials
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  • In the top 5% of all articles scored by Altmetric
  • Among the highest-scoring articles from this source (#15 of 1,377)
  • High score compared to articles of the same age (97th percentile)
  • High score compared to articles of the same age and source (98th percentile)

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mendeley
7 Mendeley
Article title
Folding graft copolymer with pendant drug segments for co-delivery of anticancer drugs.
Published in
Biomaterials
DOI 10.1016/j.biomaterials.2014.05.004
Pubmed ID
Abstract

A graft copolymer with pendant drug segments can fold into nanostructures in a protein folding-like manner. The graft copolymer is constructed by directly polymerizing γ-camptothecin-glutamate N-carboxyanhydride (Glu(CPT)-NCA) on multiple sites of poly(ethylene glycol) (PEG)-based main chain via the ring open polymerization (ROP). The "purely" conjugated anticancer agent camptothecin (CPT) is hydrophobic and serves as the principal driving force during the folding process. When exposed to water, the obtained copolymer, together with doxorubicin (Dox), another anticancer agent, can fold into monodispersed nanocarriers (with a diameter of around 50 nm) for dual-drug delivery. Equipped with a PEG shell, the nanocarriers displayed good stability and can be internalized by a variety of cancer cell lines via the lipid raft and clathrin-mediated endocytotic pathway without premature leakage, which showed a high synergetic activity of CPT and Dox toward various cancer cells. In vivo study validated that the nanocarriers exhibited strong accumulation in tumor sites and showed a prominent anticancer activity against the lung cancer xenograft mice model compared with free drugs.

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Score in context

This article has an Altmetric score of 70. This is our high-level measure of the quality and quantity of online attention that this article has received. This score was calculated when the article was last mentioned on 09 June 2014.
All articles
#35,545
of 3,876,540 articles
Articles in Biomaterials
#15
of 1,377 articles
Articles of similar age
#2,025
of 95,918 articles
Articles of similar age in Biomaterials
#1
of 58 articles
Altmetric has tracked 3,876,540 articles across all sources so far. Compared to these this article has done particularly well and is in the 98th percentile: it's in the top 5% of all articles ever tracked by Altmetric.
So far Altmetric has tracked 1,377 articles from this source. They typically receive a little less attention than average, with a mean score of 4.0. This article has done particularly well, scoring higher than 98% of its peers.
Older articles will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this score to the 95,918 tracked articles that were published within six weeks on either side of this one in any source. This article has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this article to 58 articles from the same source and published within six weeks on either side of this one. This article has done particularly well, scoring higher than 98% of its contemporaries.