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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease
|
|---|---|
| Published in |
Blood, May 2014
|
| DOI | 10.1182/blood-2013-11-536888 |
| Pubmed ID | |
| Authors |
J Marius Munneke, Andreas T Björklund, Jenny M Mjösberg, Karin Garming-Legert, Jochem H Bernink, Bianca Blom, Cynthia Huisman, Marinus H J van Oers, Hergen Spits, Karl-Johan Malmberg, Mette D Hazenberg |
| Abstract |
Allogeneic hematopoietic stem cell transplantation (HSCT) is widely used to treat hematopoietic cell disorders, but is often complicated by graft versus host disease (GvHD) that causes severe epithelial damage. Here we have investigated longitudinally the effects of induction chemotherapy, conditioning radio-chemotherapy and allogeneic HSCT on composition, phenotype and recovery of circulating innate lymphoid cells (ILC) in 51 acute leukemia patients. We found that reconstitution of ILC1, ILC2 and NCR(-) ILC3 was slow compared to that of neutrophils and monocytes. NCR(+) ILC3 which are not present in the circulation of healthy individuals appeared both after induction chemotherapy and after allogeneic HSCT. Circulating patient ILC before transplantation as well as donor ILC after transplantation expressed activation (CD69), proliferation (Ki-67) and tissue homing markers for gut (α4β7, CCR6) and skin (CCR10 and CLA). The proportion ILC expressing these markers was associated with a decreased susceptibility to therapy-induced mucositis and acute GvHD. Taken together, these data suggest that ILC recovery and treatment-related tissue damage are interrelated and affect the development of GvHD. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 206 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Greece | 1 | <1% |
| Germany | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 202 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 40 | 19% |
| Researcher | 27 | 13% |
| Student > Master | 24 | 12% |
| Student > Bachelor | 23 | 11% |
| Student > Doctoral Student | 19 | 9% |
| Other | 28 | 14% |
| Unknown | 45 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 49 | 24% |
| Agricultural and Biological Sciences | 44 | 21% |
| Medicine and Dentistry | 41 | 20% |
| Biochemistry, Genetics and Molecular Biology | 15 | 7% |
| Engineering | 4 | 2% |
| Other | 7 | 3% |
| Unknown | 46 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2022.
All research outputs
#4,836,164
of 25,374,647 outputs
Outputs from Blood
#7,028
of 33,238 outputs
Outputs of similar age
#44,550
of 240,011 outputs
Outputs of similar age from Blood
#72
of 252 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 33,238 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,011 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 252 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.