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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Pattern recognition receptors and the inflammasome in kidney disease
|
|---|---|
| Published in |
Nature Reviews Nephrology, June 2014
|
| DOI | 10.1038/nrneph.2014.91 |
| Pubmed ID | |
| Authors |
Jaklien C. Leemans, Lotte Kors, Hans-Joachim Anders, Sandrine Florquin |
| Abstract |
Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain receptors (NLRs) are families of pattern recognition receptors that, together with inflammasomes, sense and respond to highly conserved pathogen motifs and endogenous molecules released upon cell damage or stress. Evidence suggests that TLRs, NLRs and the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome have important roles in kidney diseases through regulation of inflammatory and tissue-repair responses to infection and injury. In this Review, we discuss the pathological mechanisms that are related to TLRs, NLRs and NLRP3 in various kidney diseases. In general, these receptors are protective in the host defence against urinary tract infection, but can sustain and self-perpetuate tissue damage in sterile inflammatory and immune-mediated kidney diseases. TLRs, NLRs and NLRP3, therefore, have become promising drug targets to enable specific modulation of kidney inflammation and suppression of immunopathology in kidney disease. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 17% |
| United Kingdom | 1 | 17% |
| Unknown | 4 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 50% |
| Science communicators (journalists, bloggers, editors) | 2 | 33% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | 2% |
| Germany | 1 | <1% |
| United Kingdom | 1 | <1% |
| Netherlands | 1 | <1% |
| Spain | 1 | <1% |
| China | 1 | <1% |
| Unknown | 118 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 16% |
| Researcher | 20 | 16% |
| Student > Master | 18 | 14% |
| Student > Doctoral Student | 8 | 6% |
| Student > Bachelor | 7 | 6% |
| Other | 30 | 24% |
| Unknown | 22 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 33 | 26% |
| Agricultural and Biological Sciences | 31 | 25% |
| Biochemistry, Genetics and Molecular Biology | 12 | 10% |
| Immunology and Microbiology | 11 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 5% |
| Other | 7 | 6% |
| Unknown | 25 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 June 2014.
All research outputs
#12,706,253
of 22,757,090 outputs
Outputs from Nature Reviews Nephrology
#1,092
of 1,737 outputs
Outputs of similar age
#103,625
of 227,901 outputs
Outputs of similar age from Nature Reviews Nephrology
#15
of 40 outputs
Altmetric has tracked 22,757,090 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,737 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.3. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,901 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.