Pneumolysin expression by streptococcus pneumoniae protects colonized mice from influenza virus-induced disease.

Overview of attention for article published in Virology
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About this score

  • In the top 5% of all articles scored by Altmetric
  • One of the highest-scoring articles from this source (#4 of 1,445)
  • High score compared to articles of the same age (97th percentile)
  • High score compared to articles of the same age and source (98th percentile)

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mendeley
15 Mendeley
Article title
Pneumolysin expression by streptococcus pneumoniae protects colonized mice from influenza virus-induced disease.
Published in
Virology
DOI 10.1016/j.virol.2014.06.019
Pubmed ID
Abstract

The response to influenza virus (IAV) infection and severity of disease is highly variable in humans. We hypothesized that one factor contributing to this variability is the presence of specific respiratory tract (RT) microbes. One such microbe is Streptococcus pneumoniae (Sp) that is carried asymptomatically in the RT of many humans. In a mouse co-infection model we found that in contrast to secondary bacterial infection that exacerbates disease, Sp colonization 10 days prior to IAV protects from virus-induced morbidity and lung pathology. Using mutant Sp strains, we identified a critical role for the bacterial virulence factor pneumolysin (PLY) in mediating this protection. Colonization with the PLY-sufficient Sp strain induces expression of the immune-suppressive enzyme arginase 1 in alveolar macrophages (aMø) and correlates with attenuated recruitment and function of pulmonary inflammatory cells. Our study demonstrates a novel role for PLY in Sp-mediated protection by maintaining aMø as "gatekeepers" against virus-induced immunopathology.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this article. Click here to see the article's page on the Mendeley website.

Geographical breakdown

Country Count As %
South Africa 2 13%
United States 1 7%
Unknown 12 80%

Demographic breakdown

Readers by professional status Count As %
Senior Lecturer 2 13%
Ph.D. Student 2 13%
Student (Bachelor) 1 7%
Other Professional 1 7%
Post Doc 1 7%
Other 0 0%
Unknown 8 53%
Readers by discipline Count As %
Biological Sciences 5 33%
Social Sciences 1 7%
Medicine 1 7%
Unknown 8 53%

Score in context

This article has an Altmetric score of 59. This is our high-level measure of the quality and quantity of online attention that this article has received. This score was calculated when the article was last mentioned on 11 July 2014.
All articles
#46,110
of 4,016,618 articles
Articles in Virology
#4
of 1,445 articles
Articles of similar age
#2,589
of 99,711 articles
Articles of similar age in Virology
#1
of 58 articles
Altmetric has tracked 4,016,618 articles across all sources so far. Compared to these this article has done particularly well and is in the 98th percentile: it's in the top 5% of all articles ever tracked by Altmetric.
So far Altmetric has tracked 1,445 articles from this source. They typically receive a little less attention than average, with a mean score of 2.9. This article has done particularly well, scoring higher than 99% of its peers.
Older articles will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this score to the 99,711 tracked articles that were published within six weeks on either side of this one in any source. This article has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this article to 58 articles from the same source and published within six weeks on either side of this one. This article has done particularly well, scoring higher than 98% of its contemporaries.