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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Inhibition of the central melanocortin system decreases brown adipose tissue activity[S]
|
|---|---|
| Published in |
Journal of Lipid Research, July 2014
|
| DOI | 10.1194/jlr.m045989 |
| Pubmed ID | |
| Authors |
Sander Kooijman, Mariëtte R Boon, Edwin T Parlevliet, Janine J Geerling, Vera van de Pol, Johannes A Romijn, Louis M Havekes, Illiana Meurs, Patrick C N Rensen |
| Abstract |
The melanocortin system is an important regulator of energy balance and MC4R deficiency is the most common monogenic cause of obesity. We investigated whether the relationship between melanocortin system activity and energy expenditure is mediated by brown adipose tissue (BAT) activity. Therefore, female APOE*3-Leiden.CETP transgenic mice were fed a Western-type diet for 4 weeks and infused intracerebroventricularly with the MC3/4R antagonist SHU9119 or vehicle for 2 weeks. SHU9119 increased food intake (+30%), body fat (+50%) and decreased energy expenditure by reduction in fat oxidation (-42%). In addition, SHU9119 impaired the uptake of VLDL-TG byBAT. In line with this, SHU9119 decreased uncoupling protein-1 levels in BAT (-60%) and induced large intracellular lipid droplets, indicative of severely disturbed BAT activity. Finally, SHU9119-treated mice pair-fed to the vehicle-treated group still exhibited these effects, indicating that MC4R inhibition impairs BAT activity independent of food intake. These effects were not specific to the APOE*3-Leiden.CETP background as SHU9119 also inhibited BAT activity in wild-type mice We conclude that inhibition of central MC3/4R signaling impairs BAT function, which is accompanied by reduced energy expenditure thereby promoting adiposity. We anticipate that activation of MC4R is a promising strategy to combat obesity by increasing BAT activity. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 28 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 7 | 25% |
| Student > Ph. D. Student | 5 | 18% |
| Student > Bachelor | 4 | 14% |
| Researcher | 3 | 11% |
| Professor > Associate Professor | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 8 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 25% |
| Biochemistry, Genetics and Molecular Biology | 4 | 14% |
| Medicine and Dentistry | 3 | 11% |
| Neuroscience | 2 | 7% |
| Psychology | 1 | 4% |
| Other | 2 | 7% |
| Unknown | 9 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2016.
All research outputs
#20,656,820
of 25,374,917 outputs
Outputs from Journal of Lipid Research
#4,420
of 4,810 outputs
Outputs of similar age
#176,547
of 240,980 outputs
Outputs of similar age from Journal of Lipid Research
#24
of 27 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,810 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,980 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.