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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Increased plasma N-glycome complexity is associated with higher risk of type 2 diabetes
|
|---|---|
| Published in |
Diabetologia, September 2017
|
| DOI | 10.1007/s00125-017-4426-9 |
| Pubmed ID | |
| Authors |
Toma Keser, Ivan Gornik, Frano Vučković, Najda Selak, Tamara Pavić, Edita Lukić, Ivan Gudelj, Hrvoje Gašparović, Bojan Biočina, Therese Tilin, Annika Wennerström, Satu Männistö, Veikko Salomaa, Aki Havulinna, Wei Wang, James F. Wilson, Nishi Charutvedi, Markus Perola, Harry Campbell, Gordan Lauc, Olga Gornik |
| Abstract |
Better understanding of type 2 diabetes and its prevention is a pressing need. Changes in human plasma N-glycome are associated with many diseases and represent promising diagnostic and prognostic biomarkers. Variations in glucose metabolism directly affect glycosylation through the hexosamine pathway but studies of plasma glycome in type 2 diabetes are scarce. The aim of this study was to determine whether plasma protein N-glycome is changed in individuals who are at greater risk of developing type 2 diabetes. Using a chromatographic approach, we analysed N-linked glycans from plasma proteins in two populations comprising individuals with registered hyperglycaemia during critical illness (increased risk for development of type 2 diabetes) and individuals who stayed normoglycaemic during the same condition: AcuteInflammation (59 cases vs 49 controls) and AcuteInflammation Replication (52 cases vs 14 controls) populations. N-glycome was also studied in individuals from FinRisk (37 incident cases of type 2 diabetes collected at baseline vs 37 controls), Orkney Complex Disease Study (ORCADES; 94 individuals with HbA1c > 6.5% [47.5 mmol/mol] vs 658 controls) and Southall and Brent Revisited (SABRE) cohort studies (307 individuals with HbA1c > 6.5% [47.5 mmol/mol] vs 307 controls). Individuals with increased risk for diabetes type 2 development (AcuteInflammation and AcuteInflammation Replication populations), incident cases of type 2 diabetes collected at baseline (FinRisk population) and individuals with elevated HbA1c (ORCADES and SABRE populations) all presented with increased branching, galactosylation and sialylation of plasma protein N-glycans and these changes were of similar magnitude. Increased complexity of plasma N-glycan structures is associated with higher risk of developing type 2 diabetes and poorer regulation of blood glucose levels. Although further research is needed, this finding could offer a potential new approach for improvement in prevention of diabetes and its complications. |
X Demographics
The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 13% |
| Argentina | 1 | 7% |
| Serbia | 1 | 7% |
| Spain | 1 | 7% |
| Australia | 1 | 7% |
| Canada | 1 | 7% |
| Croatia | 1 | 7% |
| Unknown | 7 | 47% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 73% |
| Scientists | 4 | 27% |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 71 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 23% |
| Researcher | 10 | 14% |
| Student > Master | 8 | 11% |
| Student > Bachelor | 7 | 10% |
| Other | 4 | 6% |
| Other | 10 | 14% |
| Unknown | 16 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 19 | 27% |
| Medicine and Dentistry | 10 | 14% |
| Agricultural and Biological Sciences | 9 | 13% |
| Chemistry | 5 | 7% |
| Nursing and Health Professions | 2 | 3% |
| Other | 8 | 11% |
| Unknown | 18 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 January 2019.
All research outputs
#4,499,256
of 23,002,898 outputs
Outputs from Diabetologia
#1,930
of 5,088 outputs
Outputs of similar age
#78,572
of 316,290 outputs
Outputs of similar age from Diabetologia
#78
of 100 outputs
Altmetric has tracked 23,002,898 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,088 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.7. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,290 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 100 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.