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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Nutrikinetic modeling reveals order of genistein phase II metabolites appearance in human plasma
|
|---|---|
| Published in |
Molecular Nutrition & Food Research, August 2014
|
| DOI | 10.1002/mnfr.201400325 |
| Pubmed ID | |
| Authors |
Suzanne Smit, Ewa Szymańska, Iris Kunz, Victoria Gomez Roldan, Marcel W. E. M. van Tilborg, Peter Weber, Kevin Prudence, Frans M. van der Kloet, John P. M. van Duynhoven, Age K. Smilde, Ric C. H. de Vos, Igor Bendik |
| Abstract |
Genistein from foods or supplements is metabolized by the gut microbiota and the human body, thereby releasing many different metabolites into systemic circulation. The order of their appearance in plasma and the possible influence of food format are still unknown. This study compared the nutrikinetic profiles of genistein metabolites METHODS AND RESULTS: In a randomized cross-over trial, twelve healthy young volunteers were administered a single dose of 30 mg genistein provided as a genistein tablet, a genistein tablet in low fat milk, and soy milk containing genistein glycosides. A high mass resolution LC-LTQ-Orbitrap FTMS platform detected and quantified in human plasma: free genistein, seven of its phase-II metabolites and fifteen gut-derived metabolites. Interestingly, a novel metabolite, genistein-4'-glucuronide-7-sulfate (G-4'G-7S) was identified. Nutrikinetic analysis using population based modeling revealed the order of appearance of five genistein phase II metabolites in plasma: (1) genistein-4',7-diglucuronide, (2) genistein-7-sulfate, (3) genistein-4'-sulfate-7-glucuronide, (4) genistein-4'-glucuronide and (5) genistein-7-glucuronide, independent of the food matrix. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 49 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 11 | 22% |
| Researcher | 7 | 14% |
| Student > Ph. D. Student | 5 | 10% |
| Student > Bachelor | 3 | 6% |
| Professor | 3 | 6% |
| Other | 10 | 20% |
| Unknown | 10 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 10 | 20% |
| Medicine and Dentistry | 8 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 10% |
| Biochemistry, Genetics and Molecular Biology | 3 | 6% |
| Nursing and Health Professions | 3 | 6% |
| Other | 7 | 14% |
| Unknown | 13 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2014.
All research outputs
#20,233,066
of 22,758,963 outputs
Outputs from Molecular Nutrition & Food Research
#2,232
of 2,516 outputs
Outputs of similar age
#197,594
of 235,580 outputs
Outputs of similar age from Molecular Nutrition & Food Research
#21
of 26 outputs
Altmetric has tracked 22,758,963 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,516 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,580 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.