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The association between cognitive functioning and health-related quality of life in low-grade glioma patients

Overview of attention for article published in Neuro-Oncology Practice, May 2014
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Title
The association between cognitive functioning and health-related quality of life in low-grade glioma patients
Published in
Neuro-Oncology Practice, May 2014
DOI 10.1093/nop/npu007
Pubmed ID
Authors

Florien W. Boele, Maaike Zant, Emma C.E. Heine, Neil K. Aaronson, Martin J.B. Taphoorn, Jaap C. Reijneveld, Tjeerd J. Postma, Jan J. Heimans, Martin Klein

Abstract

Glioma patients are not only confronted with the diagnosis and treatment of a brain tumor, but also with changes in cognitive and neurological functioning that can profoundly affect their daily lives. At present, little is known about the relationship between cognitive functioning and health-related quality of life (HRQOL) during the disease trajectory. We studied this association in low-grade glioma (LGG) patients with stable disease at an average of 6 years after diagnosis. Patients and healthy controls underwent neuropsychological testing and completed self-report measures of generic (MOS SF36) and disease-specific (EORTC BN20) HRQOL. Associations were determined with Pearson correlations, and corrections for multiple testing were made. We analyzed data gathered from 190 LGG patients. Performance in all cognitive domains was positively associated with physical health (SF36 Physical Component Summary). Executive functioning, processing speed, working memory, and information processing were positively associated with mental health (SF36 Mental Component Summary). We found negative associations between a wide range of cognitive domains and disease-specific HRQOL scales. In stable LGG patients, poorer cognitive functioning is related to lower generic and disease-specific HRQOL. This confirms that cognitive assessment of LGG patients should not be done in isolation from assessment of its impact on HRQOL, both in clinical and in research settings.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 1 1%
Australia 1 1%
Unknown 78 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 18%
Student > Master 11 14%
Student > Postgraduate 8 10%
Other 7 9%
Student > Bachelor 5 6%
Other 16 20%
Unknown 19 24%
Readers by discipline Count As %
Medicine and Dentistry 24 30%
Psychology 19 24%
Neuroscience 6 8%
Biochemistry, Genetics and Molecular Biology 2 3%
Engineering 2 3%
Other 5 6%
Unknown 22 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 September 2015.
All research outputs
#14,663,254
of 25,466,764 outputs
Outputs from Neuro-Oncology Practice
#182
of 386 outputs
Outputs of similar age
#118,005
of 242,052 outputs
Outputs of similar age from Neuro-Oncology Practice
#2
of 5 outputs
Altmetric has tracked 25,466,764 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 386 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,052 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.