Title |
Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase
|
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Published in |
Cell Death & Differentiation, August 2014
|
DOI | 10.1038/cdd.2014.135 |
Pubmed ID | |
Authors |
S Maniam, A S Coutts, M R Stratford, J McGouran, B Kessler, N B La Thangue |
Abstract |
Metabolic reprogramming is a hallmark of cancer cells. Strap (stress-responsive activator of p300) is a novel TPR motif OB-fold protein that contributes to p53 transcriptional activation. We show here that, in addition to its established transcriptional role, Strap is localised at mitochondria where one of its key interaction partners is ATP synthase. Significantly, the interaction between Strap and ATP synthase downregulates mitochondrial ATP production. Under glucose-limiting conditions, cancer cells are sensitised by mitochondrial Strap to apoptosis, which is rescued by supplementing cells with an extracellular source of ATP. Furthermore, Strap augments the apoptotic effects of mitochondrial p53. These findings define Strap as a dual regulator of cellular reprogramming: first as a nuclear transcription cofactor and second in the direct regulation of mitochondrial respiration.Cell Death and Differentiation advance online publication, 29 August 2014; doi:10.1038/cdd.2014.135. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Korea, Republic of | 1 | 3% |
Unknown | 28 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 31% |
Researcher | 8 | 28% |
Student > Master | 3 | 10% |
Professor | 2 | 7% |
Student > Postgraduate | 2 | 7% |
Other | 2 | 7% |
Unknown | 3 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 15 | 52% |
Agricultural and Biological Sciences | 6 | 21% |
Psychology | 1 | 3% |
Medicine and Dentistry | 1 | 3% |
Neuroscience | 1 | 3% |
Other | 1 | 3% |
Unknown | 4 | 14% |