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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genomically encoded analog memory with precise in vivo DNA writing in living cell populations
|
|---|---|
| Published in |
Science, November 2014
|
| DOI | 10.1126/science.1256272 |
| Pubmed ID | |
| Authors |
Fahim Farzadfard, Timothy K Lu |
| Abstract |
Cellular memory is crucial to many natural biological processes and sophisticated synthetic biology applications. Existing cellular memories rely on epigenetic switches or recombinases, which are limited in scalability and recording capacity. In this work, we use the DNA of living cell populations as genomic "tape recorders" for the analog and distributed recording of long-term event histories. We describe a platform for generating single-stranded DNA (ssDNA) in vivo in response to arbitrary transcriptional signals. When coexpressed with a recombinase, these intracellularly expressed ssDNAs target specific genomic DNA addresses, resulting in precise mutations that accumulate in cell populations as a function of the magnitude and duration of the inputs. This platform could enable long-term cellular recorders for environmental and biomedical applications, biological state machines, and enhanced genome engineering strategies. |
X Demographics
The data shown below were collected from the profiles of 110 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 18 | 16% |
| United Kingdom | 11 | 10% |
| Spain | 5 | 5% |
| Belgium | 5 | 5% |
| France | 4 | 4% |
| Canada | 3 | 3% |
| Germany | 3 | 3% |
| India | 3 | 3% |
| Japan | 2 | 2% |
| Other | 10 | 9% |
| Unknown | 46 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 69 | 63% |
| Scientists | 35 | 32% |
| Science communicators (journalists, bloggers, editors) | 4 | 4% |
| Practitioners (doctors, other healthcare professionals) | 2 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 868 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 22 | 3% |
| United Kingdom | 5 | <1% |
| China | 3 | <1% |
| Germany | 3 | <1% |
| Japan | 2 | <1% |
| Argentina | 2 | <1% |
| Canada | 2 | <1% |
| Spain | 2 | <1% |
| Sweden | 2 | <1% |
| Other | 10 | 1% |
| Unknown | 815 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 241 | 28% |
| Researcher | 174 | 20% |
| Student > Bachelor | 106 | 12% |
| Student > Master | 73 | 8% |
| Professor | 43 | 5% |
| Other | 140 | 16% |
| Unknown | 91 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 342 | 39% |
| Biochemistry, Genetics and Molecular Biology | 218 | 25% |
| Engineering | 56 | 6% |
| Chemistry | 26 | 3% |
| Computer Science | 22 | 3% |
| Other | 95 | 11% |
| Unknown | 109 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 333. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2024.
All research outputs
#101,078
of 26,017,215 outputs
Outputs from Science
#3,334
of 83,593 outputs
Outputs of similar age
#843
of 274,023 outputs
Outputs of similar age from Science
#36
of 817 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,593 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.8. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,023 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 817 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.