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Metabolic functions of peroxisomes in health and disease

Overview of attention for article published in Biochimie, September 2013
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Title
Metabolic functions of peroxisomes in health and disease
Published in
Biochimie, September 2013
DOI 10.1016/j.biochi.2013.08.022
Pubmed ID
Authors

Ronald J.A. Wanders

Abstract

Peroxisomes are subcellular organelles which are present in virtually every eukaryotic cell and catalyze a large number of metabolic functions. The importance of peroxisomes for humans is stressed by the existence of a large group of genetic diseases in which either the biogenesis of peroxisomes is impaired or one of its metabolic functions. Thanks to the work on Zellweger syndrome which is the prototype of the group of peroxisomal disorders, much has been learned about the metabolism and biogenesis of peroxisomes in humans. These metabolic functions include: (1.) fatty acid beta-oxidation; (2.) etherphospholipid biosynthesis; (3.) fatty acid alpha-oxidation, and (4.) glyoxylate detoxification. Since peroxisomes lack a citric acid cycle and a respiratory chain, peroxisomes are relatively helpless organelles which rely heavily on their cross-talk with other subcellular organelles in order to metabolize the end products of metabolism as generated in peroxisomes. The metabolic functions of peroxisomes in humans will be briefly described in this review with emphasis on the cross-talk with other subcellular organelles as well as the peroxisomal disorders in which one or more peroxisomal functions are impaired.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 278 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 4 1%
Portugal 1 <1%
Netherlands 1 <1%
Chile 1 <1%
Canada 1 <1%
Mexico 1 <1%
Spain 1 <1%
Unknown 268 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 61 22%
Researcher 43 15%
Student > Bachelor 43 15%
Student > Master 31 11%
Other 10 4%
Other 33 12%
Unknown 57 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 87 31%
Agricultural and Biological Sciences 72 26%
Medicine and Dentistry 26 9%
Neuroscience 9 3%
Chemistry 9 3%
Other 16 6%
Unknown 59 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 July 2015.
All research outputs
#19,944,091
of 25,373,627 outputs
Outputs from Biochimie
#1,942
of 2,582 outputs
Outputs of similar age
#151,231
of 208,959 outputs
Outputs of similar age from Biochimie
#33
of 43 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,582 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 208,959 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.