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Quantitative and qualitative symptomatic differences in individuals at Ultra-High Risk for psychosis and healthy controls

Overview of attention for article published in Psychiatry Research, August 2013
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Title
Quantitative and qualitative symptomatic differences in individuals at Ultra-High Risk for psychosis and healthy controls
Published in
Psychiatry Research, August 2013
DOI 10.1016/j.psychres.2013.07.018
Pubmed ID
Authors

Eva Velthorst, Eske M. Derks, Patricia Schothorst, Hiske Becker, Sarah Durston, Tim Ziermans, Dorien H. Nieman, Lieuwe de Haan

Abstract

Patients at Ultra-High Risk (UHR) for developing a first psychosis vary widely in their symptom presentation and illness course. An important aim in UHR research concerns the characterization of the clinical heterogeneity in this population. We aimed to identify qualitatively and quantitatively different clinical symptom profiles at baseline and at 2-year follow-up in a group of UHR subjects and healthy controls. We employed a Latent Class Factor Analysis (LCFA) to the 19 items of the Structured Interview for Prodromal Syndromes (SIPS) ratings at baseline and at 2-year follow-up in a sample of 147 UHR subjects and 141 controls from the Dutch Prediction of Psychosis Study (DUPS) in the Netherlands. Additionally, a stepwise logistic regression analysis was performed with transition to psychosis as a dependent variable and baseline latent variable scores as predictors. Variation in symptomatology at baseline was explained by both quantitative and qualitative differences; at 2-year follow-up qualitative differences between individuals were no longer observed. Quantitative differences showed moderate stability over time (range=0.109-0.42). Within the UHR sample, transition to psychosis was significantly associated with quantitative differences in baseline SIPS scores. The results of our study suggest a 'quasi'-continuous extended psychosis phenotype, a finding that merits replication in other samples.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 2%
Unknown 65 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 17%
Researcher 9 14%
Student > Master 8 12%
Student > Postgraduate 6 9%
Student > Bachelor 4 6%
Other 13 20%
Unknown 15 23%
Readers by discipline Count As %
Psychology 19 29%
Medicine and Dentistry 11 17%
Neuroscience 6 9%
Agricultural and Biological Sciences 3 5%
Social Sciences 2 3%
Other 6 9%
Unknown 19 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2014.
All research outputs
#22,759,452
of 25,374,647 outputs
Outputs from Psychiatry Research
#6,732
of 7,587 outputs
Outputs of similar age
#186,393
of 209,329 outputs
Outputs of similar age from Psychiatry Research
#135
of 142 outputs
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