| Title |
Variation in cancer risk among tissues can be explained by the number of stem cell divisions
|
|---|---|
| Published in |
Science, January 2015
|
| DOI | 10.1126/science.1260825 |
| Pubmed ID | |
| Authors |
Cristian Tomasetti, Bert Vogelstein |
| Abstract |
Some tissue types give rise to human cancers millions of times more often than other tissue types. Although this has been recognized for more than a century, it has never been explained. Here, we show that the lifetime risk of cancers of many different types is strongly correlated (0.81) with the total number of divisions of the normal self-renewing cells maintaining that tissue's homeostasis. These results suggest that only a third of the variation in cancer risk among tissues is attributable to environmental factors or inherited predispositions. The majority is due to "bad luck," that is, random mutations arising during DNA replication in normal, noncancerous stem cells. This is important not only for understanding the disease but also for designing strategies to limit the mortality it causes. |
X Demographics
The data shown below were collected from the profiles of 1,129 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 219 | 19% |
| Japan | 111 | 10% |
| United Kingdom | 68 | 6% |
| Spain | 44 | 4% |
| Canada | 24 | 2% |
| Netherlands | 24 | 2% |
| France | 17 | 2% |
| Germany | 14 | 1% |
| Australia | 11 | <1% |
| Other | 126 | 11% |
| Unknown | 471 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 809 | 72% |
| Scientists | 233 | 21% |
| Practitioners (doctors, other healthcare professionals) | 64 | 6% |
| Science communicators (journalists, bloggers, editors) | 23 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 2,922 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 43 | 1% |
| Germany | 23 | <1% |
| United Kingdom | 18 | <1% |
| France | 10 | <1% |
| Italy | 6 | <1% |
| Denmark | 5 | <1% |
| Canada | 5 | <1% |
| Japan | 4 | <1% |
| Switzerland | 4 | <1% |
| Other | 42 | 1% |
| Unknown | 2762 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 648 | 22% |
| Researcher | 631 | 22% |
| Student > Bachelor | 324 | 11% |
| Student > Master | 256 | 9% |
| Other | 159 | 5% |
| Other | 551 | 19% |
| Unknown | 353 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 855 | 29% |
| Biochemistry, Genetics and Molecular Biology | 634 | 22% |
| Medicine and Dentistry | 433 | 15% |
| Chemistry | 66 | 2% |
| Engineering | 64 | 2% |
| Other | 431 | 15% |
| Unknown | 439 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3000. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2024.
All research outputs
#2,227
of 25,732,188 outputs
Outputs from Science
#124
of 83,266 outputs
Outputs of similar age
#13
of 361,116 outputs
Outputs of similar age from Science
#3
of 1,064 outputs
Altmetric has tracked 25,732,188 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,266 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 66.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,116 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1,064 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.