Title |
Myeloid-related protein-8/14 facilitates bacterial growth during pneumococcal pneumonia
|
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Published in |
Thorax, September 2014
|
DOI | 10.1136/thoraxjnl-2014-205668 |
Pubmed ID | |
Authors |
Ahmed Achouiti, Thomas Vogl, Henrik Endeman, Brittany L Mortensen, Pierre-Francois Laterre, Xavier Wittebole, Marieke A D van Zoelen, Yaofang Zhang, Jacobien J Hoogerwerf, Sandrine Florquin, Marcus J Schultz, Jan C Grutters, Douwe H Biesma, Johannes Roth, Eric P Skaar, Cornelis van 't Veer, Alex F de Vos, Tom van der Poll |
Abstract |
Streptococcus pneumoniae is the most commonly identified pathogen in community-acquired pneumonia (CAP). Myeloid-related protein (MRP) 8/14 is a major component of neutrophils that is released upon infection or injury. MRP8/14 is essential for protective immunity during infection by a variety of micro-organisms through its capacity to chelate manganese and zinc. Here, we aimed to determine the role of MRP8/14 in pneumococcal pneumonia. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
Unknown | 42 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 14% |
Researcher | 5 | 12% |
Student > Bachelor | 4 | 9% |
Other | 4 | 9% |
Student > Master | 4 | 9% |
Other | 6 | 14% |
Unknown | 14 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 37% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
Agricultural and Biological Sciences | 3 | 7% |
Chemistry | 2 | 5% |
Biochemistry, Genetics and Molecular Biology | 1 | 2% |
Other | 5 | 12% |
Unknown | 13 | 30% |