You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Mendeley readers
Attention Score in Context
| Title |
Cortical beta amyloid protein triggers an immune response, but no synaptic changes in the APPswe/PS1dE9 Alzheimer's disease mouse model
|
|---|---|
| Published in |
Neurobiology of Aging, December 2012
|
| DOI | 10.1016/j.neurobiolaging.2012.11.008 |
| Pubmed ID | |
| Authors |
Kerstin T.S. Wirz, Koen Bossers, Anita Stargardt, Willem Kamphuis, Dick F. Swaab, Elly M. Hol, Joost Verhaagen |
| Abstract |
Using microarray technology we studied the genome-wide gene expression profiles in the frontal cortex of APPswe/PS1dE9 mice and age and sex-matched littermates at the age of 2, 3, 6, 9, 12, and 15-18 months to investigate transcriptional changes that are associated with beta amyloid protein (Aβ) plaque formation and buildup. We observed the occurrence of an immune response with glial activation, but no changes in genes involved in synaptic transmission or plasticity. Comparison of the mouse gene expression data set with a human data set representing the course of Alzheimer's disease revealed a strikingly limited overlap between gene expression in the APPswe/PS1dE9 and human Alzheimer's disease prefrontal cortex. Only plexin domain containing 2, complement component 4b, and solute carrier family 14 (urea transporter) member 1 were significantly upregulated in the mouse and human brain which might suggest a function in Aβ pathology for these 3 genes. In both data sets we detected clusters of upregulated genes involved in immune-related processes. We conclude that the APPswe/PS1dE9 mouse can be a good model to study the immune response associated with cortical Aβ plaques. |
Mendeley readers
The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Indonesia | 1 | <1% |
| Netherlands | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 114 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 28% |
| Student > Master | 19 | 16% |
| Researcher | 18 | 15% |
| Student > Bachelor | 12 | 10% |
| Other | 6 | 5% |
| Other | 14 | 12% |
| Unknown | 15 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 27 | 23% |
| Agricultural and Biological Sciences | 22 | 19% |
| Medicine and Dentistry | 14 | 12% |
| Biochemistry, Genetics and Molecular Biology | 8 | 7% |
| Computer Science | 5 | 4% |
| Other | 23 | 20% |
| Unknown | 18 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 January 2015.
All research outputs
#6,525,286
of 25,371,288 outputs
Outputs from Neurobiology of Aging
#2,237
of 4,418 outputs
Outputs of similar age
#62,520
of 286,174 outputs
Outputs of similar age from Neurobiology of Aging
#12
of 36 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 4,418 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,174 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.