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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction
|
|---|---|
| Published in |
JACC: Basic to Translational Science, December 2017
|
| DOI | 10.1016/j.jacbts.2017.06.007 |
| Pubmed ID | |
| Authors |
Thomas E. Sharp, Hajime Kubo, Remus M. Berretta, Timothy Starosta, Markus Wallner, Giana J. Schena, Alexander R. Hobby, Daohai Yu, Danielle M. Trappanese, Jon C. George, Jeffery D. Molkentin, Steven R. Houser |
| Abstract |
Inotropic support is often required to stabilize the hemodynamics of patients with acute decompensated heart failure; while efficacious, it has a history of leading to lethal arrhythmias and/or exacerbating contractile and energetic insufficiencies. Novel therapeutics that can improve contractility independent of beta-adrenergic and protein kinase A-regulated signaling, should be therapeutically beneficial. This study demonstrates that acute protein kinase C-α/β inhibition, with ruboxistaurin at 3 months' post-myocardial infarction, significantly increases contractility and reduces the end-diastolic/end-systolic volumes, documenting beneficial remodeling. These data suggest that ruboxistaurin represents a potential novel therapeutic for heart failure patients, as a moderate inotrope or therapeutic, which leads to beneficial ventricular remodeling. |
X Demographics
The data shown below were collected from the profiles of 39 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 10% |
| Chile | 4 | 10% |
| United States | 4 | 10% |
| Venezuela, Bolivarian Republic of | 3 | 8% |
| Spain | 3 | 8% |
| Colombia | 2 | 5% |
| Canada | 2 | 5% |
| Ecuador | 1 | 3% |
| Mexico | 1 | 3% |
| Other | 5 | 13% |
| Unknown | 10 | 26% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 23 | 59% |
| Practitioners (doctors, other healthcare professionals) | 9 | 23% |
| Scientists | 5 | 13% |
| Science communicators (journalists, bloggers, editors) | 2 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 23 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 17% |
| Student > Doctoral Student | 3 | 13% |
| Student > Ph. D. Student | 2 | 9% |
| Student > Master | 2 | 9% |
| Student > Bachelor | 1 | 4% |
| Other | 5 | 22% |
| Unknown | 6 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 35% |
| Agricultural and Biological Sciences | 2 | 9% |
| Biochemistry, Genetics and Molecular Biology | 2 | 9% |
| Sports and Recreations | 2 | 9% |
| Nursing and Health Professions | 1 | 4% |
| Other | 3 | 13% |
| Unknown | 5 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2024.
All research outputs
#1,373,564
of 25,782,229 outputs
Outputs from JACC: Basic to Translational Science
#116
of 826 outputs
Outputs of similar age
#30,789
of 451,605 outputs
Outputs of similar age from JACC: Basic to Translational Science
#6
of 14 outputs
Altmetric has tracked 25,782,229 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 826 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.8. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 451,605 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.