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Two type II keratin genes are localized on human chromosome 12

Overview of attention for article published in Human Genetics, May 1989
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Title
Two type II keratin genes are localized on human chromosome 12
Published in
Human Genetics, May 1989
DOI 10.1007/bf00284039
Pubmed ID
Authors

N. C. Popescu, P. E. Bowden, J. A. DiPaolo

Abstract

Human genomic DNA containing two type II keratin genes, one coding for keratin 1 (K1, a 68-kD basic protein) and another closely linked type II gene 10-15 kb upstream (K?, gene product unknown), was isolated on a single cosmid clone. EcoRI restriction fragments of the cosmid were subcloned into pGEM-3Z, and specific probes comprising the C-terminal coding and 3' noncoding regions of the two genes were constructed. The type II keratin genes were localized by in situ hybridization of the subcloned probes to normal human lymphocyte chromosomes. In a total of 70 chromosome spreads hybridized with the K? probe (gHK?-3', PstI, 800 bp), 36 of the 105 grains observed were on chromosome 12, and 32 of these were clustered on the long arm near the centromere (12q11-13). In 100 labeled metaphases hybridized with the K1 probe (gHK1-3', BamHI-PstI, 2100 bp), 53 grains localized to chromosome 12 and 46 of these were found in the same region (q11-13). Therefore, both the gene for human keratin 1, a specific marker for terminal differentiation in mammalian epidermis, and another closely linked unknown type II keratin gene (K?, 10-15 kb upstream of K1) are on the long arm (q11-13) of human chromosome 12.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 4 100%

Demographic breakdown

Readers by professional status Count As %
Professor 1 25%
Professor > Associate Professor 1 25%
Researcher 1 25%
Unknown 1 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 2 50%
Biochemistry, Genetics and Molecular Biology 1 25%
Unknown 1 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2008.
All research outputs
#7,755,290
of 23,577,654 outputs
Outputs from Human Genetics
#958
of 2,993 outputs
Outputs of similar age
#4,131
of 14,684 outputs
Outputs of similar age from Human Genetics
#5
of 21 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,993 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
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