Title |
Effects of Vedolizumab Therapy on Extraintestinal Manifestations in Inflammatory Bowel Disease
|
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Published in |
Digestive Diseases and Sciences, February 2018
|
DOI | 10.1007/s10620-018-4971-1 |
Pubmed ID | |
Authors |
Mark Fleisher, Jan Marsal, Scott D. Lee, Laura E. Frado, Alyssa Parian, Burton I. Korelitz, Brian G. Feagan |
Abstract |
Approximately 15-20% of ulcerative colitis patients and 20-40% of those with Crohn's disease experience extraintestinal manifestations (EIMs) of their inflammatory bowel disease (IBD). Clinicians who treat IBD must manage EIMs affecting multiple organs that variably correlate with intestinal disease activity. Vedolizumab is a monoclonal antibody for the treatment of IBD with a gut-selective mechanism of action. This report evaluates whether vedolizumab is an effective treatment of EIMs, given its gut-specific mechanism of action. We report 8 case studies of patients with various EIMs, including pyoderma gangrenosum, peripheral arthralgia/arthritis, axial arthropathies, erythema nodosum, and uveitis, who received vedolizumab therapy. Vedolizumab therapy was effective for pyoderma gangrenosum in ulcerative colitis, uveitis, erythema nodosum, polyarticular arthropathy, and ankylosing spondylitis/sacroiliitis but did not provide sustained benefit for the treatment of pyoderma gangrenosum in a patient with Crohn's disease. These cases demonstrate the potential of vedolizumab as a treatment of EIMs in patients with IBD. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
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Unknown | 121 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Postgraduate | 17 | 14% |
Researcher | 15 | 12% |
Other | 11 | 9% |
Student > Master | 11 | 9% |
Student > Bachelor | 8 | 7% |
Other | 28 | 23% |
Unknown | 31 | 26% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 61 | 50% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
Nursing and Health Professions | 5 | 4% |
Immunology and Microbiology | 3 | 2% |
Arts and Humanities | 2 | 2% |
Other | 8 | 7% |
Unknown | 37 | 31% |