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Mendeley readers
Attention Score in Context
| Title |
Evolving concepts in advanced glycation, diabetic nephropathy, and diabetic vascular disease
|
|---|---|
| Published in |
Molecular Cell Biology Research Communications, November 2003
|
| DOI | 10.1016/j.abb.2003.08.017 |
| Pubmed ID | |
| Authors |
George Jerums, Sianna Panagiotopoulos, Josephine Forbes, Tanya Osicka, Mark Cooper |
| Abstract |
Advanced glycation endproducts (AGEs) have been postulated to play a role in the development of both nephropathy and large vessel disease in diabetes. However, it is still not clear which AGE subtypes play a pathogenetic role and which of several AGE receptors mediate AGE effects on cells. This review summarises the renoprotective effect of inhibitors of AGE formation, including aminoguanidine, and of cross-link breakers, including ALT-711, on experimental diabetic nephropathy and on mesenteric vascular hypertrophy. It also demonstrates similar effects of aminoguanidine and ramipril (an angiotensin converting enzyme inhibitor) on fluorescent and immunoassayable AGE levels, renal protein kinase C activity, nitrotyrosine expression, lysosomal function, and protein handling in experimental diabetes. These findings indicate that inhibition of the renin angiotensin system blocks both upstream and downstream pathways leading to tissue injury. We postulate that the chemical pathways leading to advanced glycation endproduct formation and the renin angiotensin systems may interact through the generation of free radicals, induced both by glucose and angiotensin II. There is also evidence to suggest that AGE-dependent pathways may play a role in the development of tubulointerstitial fibrosis in the diabetic kidney. This effect is mediated through RAGE and is TGF-beta and CTGF-dependent. |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 7% |
| Unknown | 26 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 18% |
| Student > Ph. D. Student | 4 | 14% |
| Student > Master | 4 | 14% |
| Professor > Associate Professor | 3 | 11% |
| Professor | 3 | 11% |
| Other | 6 | 21% |
| Unknown | 3 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 36% |
| Agricultural and Biological Sciences | 5 | 18% |
| Medicine and Dentistry | 4 | 14% |
| Chemistry | 2 | 7% |
| Nursing and Health Professions | 1 | 4% |
| Other | 4 | 14% |
| Unknown | 2 | 7% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2015.
All research outputs
#3,138,147
of 25,371,288 outputs
Outputs from Molecular Cell Biology Research Communications
#185
of 6,225 outputs
Outputs of similar age
#4,936
of 57,107 outputs
Outputs of similar age from Molecular Cell Biology Research Communications
#6
of 34 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,225 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 57,107 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.