| Title |
Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring
|
|---|---|
| Published in |
Reproductive Biology and Endocrinology, April 2015
|
| DOI | 10.1186/s12958-015-0028-x |
| Pubmed ID | |
| Authors |
Rakesh Sharma, Ashok Agarwal, Vikram K Rohra, Mourad Assidi, Muhammad Abu-Elmagd, Rola F Turki |
| Abstract |
Over the last decade, there has been a significant increase in average paternal age when the first child is conceived, either due to increased life expectancy, widespread use of contraception, late marriages and other factors. While the effect of maternal ageing on fertilization and reproduction is well known and several studies have shown that women over 35 years have a higher risk of infertility, pregnancy complications, spontaneous abortion, congenital anomalies, and perinatal complications. The effect of paternal age on semen quality and reproductive function is controversial for several reasons. First, there is no universal definition for advanced paternal ageing. Secondly, the literature is full of studies with conflicting results, especially for the most common parameters tested. Advancing paternal age also has been associated with increased risk of genetic disease. Our exhaustive literature review has demonstrated negative effects on sperm quality and testicular functions with increasing paternal age. Epigenetics changes, DNA mutations along with chromosomal aneuploidies have been associated with increasing paternal age. In addition to increased risk of male infertility, paternal age has also been demonstrated to impact reproductive and fertility outcomes including a decrease in IVF/ICSI success rate and increasing rate of preterm birth. Increasing paternal age has shown to increase the incidence of different types of disorders like autism, schizophrenia, bipolar disorders, and childhood leukemia in the progeny. It is thereby essential to educate the infertile couples on the disturbing links between increased paternal age and rising disorders in their offspring, to better counsel them during their reproductive years. |
X Demographics
The data shown below were collected from the profiles of 196 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 32 | 16% |
| South Africa | 8 | 4% |
| Nigeria | 8 | 4% |
| United Kingdom | 5 | 3% |
| Canada | 4 | 2% |
| Australia | 2 | 1% |
| Uganda | 1 | <1% |
| Poland | 1 | <1% |
| Georgia | 1 | <1% |
| Other | 12 | 6% |
| Unknown | 122 | 62% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 173 | 88% |
| Practitioners (doctors, other healthcare professionals) | 11 | 6% |
| Scientists | 7 | 4% |
| Science communicators (journalists, bloggers, editors) | 5 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 536 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 533 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 84 | 16% |
| Researcher | 72 | 13% |
| Student > Master | 61 | 11% |
| Student > Ph. D. Student | 55 | 10% |
| Student > Postgraduate | 27 | 5% |
| Other | 111 | 21% |
| Unknown | 126 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 130 | 24% |
| Biochemistry, Genetics and Molecular Biology | 69 | 13% |
| Agricultural and Biological Sciences | 66 | 12% |
| Psychology | 27 | 5% |
| Nursing and Health Professions | 22 | 4% |
| Other | 71 | 13% |
| Unknown | 151 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 547. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2024.
All research outputs
#45,321
of 25,768,270 outputs
Outputs from Reproductive Biology and Endocrinology
#4
of 1,144 outputs
Outputs of similar age
#399
of 280,782 outputs
Outputs of similar age from Reproductive Biology and Endocrinology
#2
of 25 outputs
Altmetric has tracked 25,768,270 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,144 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,782 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.