Title |
Looking beyond the details: a rise in system-oriented approaches in genetics and molecular biology
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Published in |
Current Genetics, April 2002
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DOI | 10.1007/s00294-002-0285-z |
Pubmed ID | |
Authors |
Hiroaki Kitano |
Abstract |
With the ever-increasing flow of high-throughput gene expression, protein interaction and genome sequence data, researchers gradually approach a system-level understanding of cells and even multi-cellular organisms. Systems biology is an emerging field that enables us to achieve in-depth understanding at the system level. For this, we need to establish methodologies and techniques that enable us to understand biological systems as systems, which means to understand: (1) the structure of the system, such as gene/metabolic/signal transduction networks and physical structures, (2) the dynamics of such systems, (3) methods to control systems, and (4) methods to design and modify systems to generate desired properties. However, the meaning of "system-level understanding" is still ambiguous. This paper reviews the current status of the field and outlines future research directions and issues that need to be addressed. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 5 | 5% |
Spain | 3 | 3% |
Germany | 2 | 2% |
Brazil | 1 | <1% |
South Africa | 1 | <1% |
Norway | 1 | <1% |
Slovakia | 1 | <1% |
Colombia | 1 | <1% |
Mexico | 1 | <1% |
Other | 1 | <1% |
Unknown | 85 | 83% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 26 | 25% |
Researcher | 18 | 18% |
Student > Master | 13 | 13% |
Professor > Associate Professor | 12 | 12% |
Student > Bachelor | 7 | 7% |
Other | 18 | 18% |
Unknown | 8 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 42 | 41% |
Biochemistry, Genetics and Molecular Biology | 10 | 10% |
Computer Science | 9 | 9% |
Engineering | 7 | 7% |
Physics and Astronomy | 4 | 4% |
Other | 19 | 19% |
Unknown | 11 | 11% |